Introduction/Background*Recurrent or advanced endometrial cancer (EC) affects 2527 to 3245 women in Germany each year, with median survival of <1 year for patients with progression on or after first-line platinum therapy. Patients in this population have limited treatment options.
Methodology This study was a retrospective, noninterventional, cohort analysis that used claims data from the AOK PLUS, a statutory health insurance provider, from 01/01/2010 to 30/06/2020 for about 3.4 million individuals in Germany. Eligible patients were >18 years old, had ≥2 outpatient specialist-confirmed EC diagnoses or 1 respective inpatient diagnosis between 01/01/2011 and 30/06/2019, and 1 documented platinum-based treatment. Start of a subsequent line of treatment (LOT) after platinum was defined as the add-on of a substance or the switch to a new substance ≥3 months after regimen start. Any treatment after a gap of >3 months was also considered a new LOT. Postplatinum therapy initiation (index) was defined as the date of the first claim for an EC drug after the end of prior platinum-based therapy.
Result(s)*We identified 6832 patients with EC diagnosis. Of these, 716 received a platinum-based treatment, with 201 receiving ≥1 postplatinum treatment. Median age was 71 years (35–86 years). Median (postindex) survival was 335.00 days (95% CI, 276.29–393.71 days; figure 1). Overall, 39.3% of patients received >1 LOT, 10.4% received >2 LOTs, and 2.0% received >3 LOTs after their first platinum-based treatment. The most frequent postplatinum regimen was chemotherapy with 2 agents (10.0%; table 1). Other frequently used regimens were medroxyprogesterone (8.0%), doxorubicin (7.0%), carboplatin with paclitaxel (5.5%), and paclitaxel monotherapy (4.0%).
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