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1112 A national retrospective study on efficacy of exclusive (chemo)radiotherapy for vulvar cancer
  1. C Casà1,
  2. L Tagliaferri1,
  3. M Ferioli2,
  4. V Lancellotta1,
  5. M Boccardi3,
  6. A Cerrotta4,
  7. F Tortoreto5,
  8. E Ippolito6,
  9. C Laliscia7,
  10. A Huscher8,
  11. S Gribaudo9,
  12. A Giuseppe2,
  13. R Lazzari10,
  14. G Garganese11 and
  15. G Macchia3
  1. 1Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Rome, Italy
  2. 2IRCCS Azienda Ospedaliero-Universitaria di Bologna – Alma Mater Studiorum University of Bologna, Radiation Oncology, Department of Experimental, Diagnostic and Specialty Medicine – DIMES, Bologna, Italy
  3. 3Gemelli Molise Hospital – Università Cattolica del Sacro Cuore, Radiation Oncology Unit, Campobasso, Italy
  4. 4Fondazione IRCCS Istituto Nazionale dei Tumori, Radiotherapy Unit, Milan, Italy
  5. 5Ospedale San Pietro Fatebenefratelli, Radiotherapy Unit, Rome, Italy
  6. 6Università Campus Bio-Medico, Radiation Oncology, Rome, Italy
  7. 7University of Pisa, Department of New Technologies and Translational Research, Division of Radiation Oncology, Pisa, Italy
  8. 8Fondazione Poliambulanza, U.O. di Radioterapia Oncologica “Guido Berlucchi”, Brescia, Italy
  9. 9A.O.U “Città della Salute e della Scienza”, Dipartimento di Oncologia P.O. S. Anna – SS Radioterapia, Turin, Italy
  10. 10IEO European Institute of Oncology IRCCS, Division of Radiotherapy, Milan, Italy
  11. 11Mater Olbia Hospital, Gynecology and Breast Care Center, Olbia, Italy


Introduction/Background*Vulvar cancer (VC) is a rare gynaecologic cancer with poor outcomes in locally advanced disease. This study aims to evaluate in a retrospective, multicentred, real-world dataset of patients affected by VC efficacy and safety of exclusive (chemo)radiotherapy (eRT), focusing especially to the treatment prescription among participant centers joining the Observational itaLian stuDy on vuLvar cAncer radical raDiotherapY (OLDLADY) project endorsed by the GYN study group of the AIRO (Italian Association of Radiotherapy and Clinical Oncology).

Methodology Patients affected by VC and treated by eRT from January 2010 to December 2018 in Seven Italian radiotherapy centers were retrospectively included and clinical data were collected, analysing tumour staging, treatment prescription, clinical and toxicity outcomes.

Result(s)*The multicentred retrospective cohort was composed by 90 patients (patient populations shown in table 1), with a median age of 76 years (range 32-92). A considerable heterogeneity was found in the treatment prescription, radiotherapy doses and concomitant chemotherapy schedules. The most relevant acute toxicity revealed for the patient cohort was skin toxicity (26%); instead, the rate of severe skin fibrosis was 4.4%. After a median follow-up of 10 months (range 1-199), the 2-year actuarial local control rate (LC), the 2-year disease free survival rate (DFS) and the overall survival rate (OS) were 42.2%, 40%, and 36.7%, respectively. Kaplan-Meier curves were computed and reported in figure 1.

Abstract 1112 Figure 1

Kaplan Meier curves for LC, DFS and OS

Abstract 1112 Table 1

Study population

Conclusion*A diverse spectrum of radiotherapy options to exclusively treat patients affected by VC was reported. Clinical outcomes are still confirmed to be poor. The results suggest the clinical evaluation of the impact of treatment standardisation, in terms of doses and volumes, in a further perspective study.

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