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1109 Quality of life and sexual functioning after treatment for locally advanced cervical cancer – CCRT versus NACT-S
  1. M Tahapary1,
  2. H Toelen2,
  3. M Christiaens3,
  4. E Van Nieuwenhuysen4,
  5. T Van Gorp4,
  6. R Salihi4,
  7. IB Vergote4,
  8. P Neven4 and
  9. S Han4
  1. 1University Hospital Leuven, Gynaecology and Obstetrics, Leuven, Belgium
  2. 2University Hospital Leuven, Adult Psychiatry, Leuven, Belgium
  3. 3University Hospital Leuven, Radiotherapy Oncology, Leuven, Belgium
  4. 4University Hospital Leuven, Gynaecological Oncology, Leuven, Belgium


Introduction/Background*Locally advanced cervical cancer can be treated by concomitant chemoradiation therapy (CCRT) followed by brachytherapy or by neo-adjuvant chemotherapy followed by surgery (NACT-S). Quality of life (QoL) and sexual health (SH) are important to evaluate after treatment considering the young mean age in affected women and relatively long 5-year survival. This study aims to compare differences in QoL and SH among women treated for locally advanced cervical cancer, after CCRT versus NACT-S.

Methodology In this academic single centre cross-sectional questionnaire study, we included patients > 18 years with a history of locally advanced cervical cancer, who received either CCRT or NACT-S. QoL and SH were assessed using Dutch questionnaires including the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life core module 30 (QLQ-C30), the cervical cancer module 24 (QLQ-CX24), and sexual health questionnaire (SHQ-22). X2-test and T-test were performed to compare the two groups.

Result(s)*We sent the questionnaires to 105 women who were treated at our centre in the period between 01-01-2002 and 31-12-2018. A total of 36 patients (34%; n=12 CCRT; n=24 NACT-S) returned the questionnaire and were included for analysis. Six patients in the NACT-S group also underwent adjuvant CCRT. When comparing the CCRT and NACT-S group, 58% vs. 54% did “not at all” feel limited in their daily activities. QoL on average scored 63% vs. 67% (P= 0.29), in the CCRT and NACTS group respectively. Patients were at least “quite a bit” or “very much” satisfied with their sex life in 25% vs. 54% in the CCRT and NACT-S group, respectively (P= 0.048). A total of 33% vs. 46% did “not at all” communicate with medical professionals about sexual issues in the CCRT and NACT-S group, respectively.

Conclusion*QoL did not significantly differ when comparing the CCRT to the NACT-S group. Satisfaction with sexual life was higher in the NACT-S group. QoL and SH should receive more attention in patients with cervical cancer after treatment.

Abstract 1109 Table 1

Clinical variables.

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