Introduction/Background*Health-related quality of life (HRQoL) are increasingly recognized as important parts of treatment evaluation. Still little is known about patients‘ HRQoL after surgery and about their experiencing of symptoms. Endometrial cancer (EC) being a diagnosis with favorable prognosis and hence a large proportion of long-term survivors, the aspect of HRQoL becomes increasingly important. The study aims to explore how patients treated for EC with robotic surgery are affected in terms of health-related quality of life (HRQoL) and symptoms of anxiety and depression in the postoperative period. Furthermore, it aims to assess associations between HRQoL and patient characteristics.

Methodology Women scheduled for primary robotic surgery for EC during 1 year at a tertiary setting were invited to participate in the study. Factors including socioeconomic and civil status were obtained at baseline. Patient-reported outcomes were measured longitudinally by using the European Organization for Research and Treatment of Cancers (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30), its module for EC (EN24), the Generalized Anxiety Disorder Scale (GAD-7), and the nine-item Patient Health Questionnaire Depression Scale (PHQ-9) and followed prospectively from baseline to 2 weeks and 3 months postoperatively.

Result(s)*Sixty-four patients were included in the study. A significant decrease in Global health status (GHS) was seen at 2 weeks (from 69.8 to 62.7; p=0.048), with return to baseline levels at 3 months (68.5; p=0.32). Being unemployed (β= -36.35), having low income (β= -12.78), and receiving adjuvant therapy (β= -16.12) correlated with lower GHS at 3 months. The number of patients scoring above the clinical threshold for anxiety decreased from 17 (27.0%) at baseline to 4 (7.0%) at 2 weeks. Depressive symptoms were reported in 20% of patients at baseline and did not change significantly after 3 months.

Conclusion*Three months after robotic surgery for EC, there was no remaining negative impact on patients’ HRQoL. However, receiving adjuvant therapy, low income, unemployment, or elevated depressive symptoms prior to EC diagnosis may motivate health care providers’ increased attention.