Introduction/Background*Gynecological cancer treatment can include various types of surgery, radiation and/or chemotherapy. It can leave irreversible changes on women´s physical health and influence their psychological wellbeing affecting their quality of life. The aim of this study is to examine the quality of life of women with advanced gynecological cancer one year after diagnosis and identify possible predictive factors.

Methodology Women with endometrial, ovarian or cervical cancer included in the U-CAN (Uppsala-Umeå Comprehensive Cancer Consortium) database in years 2012-2019 were applicable for the study. Data from a general health questionnaire and the 36-item Short Form Survey (SF-36) were gathered along with information from medical records on histology, FIGO stage, type of treatment and surgical data. Inclusions criteria were completing the SF-36 at diagnosis and at one year follow up. Women with FIGO stage ≥II wore considered to have advanced gynaecological cancer.

Result(s)*The final study population (n=372) included 150 (40.3%) women in FIGO stage II or more. At diagnosis, their physical functioning and role functioning/physical scores were lower (p=0.000, p=0.001) than for women with FIGO stage 1. One year after diagnosis no difference was found in physical functioning of the two groups. Predictive factors for physical and mental health domains were identified by linear regression analyses; BMI, history of psychiatric illness and number of comorbidities were predictive for bot while education, smoking and FIGO stage ≥II were not predictive.

Conclusion*Women with advanced gynecological cancer have a good quality of life one year after diagnosis compared to women FIGO stage I disease. BMI, history of psychiatric illness and number of comorbidities are predictive factors for physical and mental health.