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943 Risk-reducing surgery in BRCA mutation: a multicentric prospective study
  1. V Loizzi,
  2. F Arezzo,
  3. CM Santarsiero,
  4. V Cataldi,
  5. C Putino,
  6. I Romagno,
  7. G Cazzato,
  8. G Serio,
  9. L Resta,
  10. E Cicinelli and
  11. G Cormio
  1. University of Bari Aldo Moro, Bari, Italy


Introduction/Background*BRCA1/2 are tumour-suppressor genes involved in DNA homologous recombination and ovarian cancer development.

Methodology Risk-reducing surgery (RRS) was performed in 148 patients carrying BRCA1 (aged between 30-73 years, median age was 51 years) and BRCA 2 mutation (aged between 36-70 years, median age was 53 years). Seventy-nine patients had previous history of breast cancer.

Result(s)*Between the all patients, 131 women underwent risk-reducing salpingo-oophorectomy (RRSO) through a laparoscopic minimally invasive approach, 11 (7,4%) underwent laparoscopic RRSO and contextual hysterectomy, 2 woman (1,3%) underwent RRSO through a laparotomic approach and 12 women (8,1%) laparotomic RRSO and hysterectomy. During 7 (4,7%) laparoscopic RRSO, prophylactic bilateral mastectomy was also performed.

Conclusion*RRSO is safe and feasible in BRCA mutation carriers. The procedure is effective for genetic prevention of ovarian cancer.

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