Article Text

Download PDFPDF

1154 The molecular profile of cutaneous metastasis from breast cancer
  1. S Sakhri1,
  2. S Kammoun2,
  3. K Hamza2,
  4. Y Houcine2,
  5. M Bouhani1,
  6. I Bettaieb2 and
  7. M Driss2
  1. 1Institut Salah Azaiz, surgical departement, Tunis, Tunisia
  2. 2Institut Salah Azaiz, anatomopathology, Tunis, Tunisia


Introduction/Background*The incidence of breast carcinoma cutaneous manifestation in patients with breast carcinoma is 23.9%. The most common sites of breast carcinoma cutaneous manifestation are the chest wall and abdomen, but they can occur at the extremities and in the head/neck region. Due the high incidence of breast carcinoma, these cutaneous manifestations are the most common metastases seen by dermatologists.

Methodology We retrospectively reported 20 cases of cutaneous metastasis from breast carcinoma diagnosed at salah azaiez institute Tunisia between 2015 and 2021.

Result(s)* there were a total of 20 cases of cutaneous metastasis from breast cancer. The average time interval between diagnosis of breast cancer and cutaneous presentation was 4years.The cutaneous sites of involvement included the head and neck (5) , the trunk (10), the extremities (3), and multiple sites (2). The age range was 38–83 <months, and the average survival following diagnosis was 3 years. The treatment consisting on surgical resection and chemotherapy in the majority of cases. Histological examination showed that in 4 cases skin metastasis change molecular profile.

Conclusion*Skin metastasis from breast cancer is frequent . The diagnosis is easy by biopsy or surgical excision.The molecular profile is variable according to the behavior and the aggressiveness of the primary tumor, an in-depth histological study is necessary to dictate the management.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.