Introduction/Background*Triple-negative breast cancer(TNBC) represent a consistent subgroup of breast cancers with heterogeneous clinical presentation, clinical behavior, histology, and response to therapy. Awareness of TNBC was recently increased by the discovery of the intrinsic molecular subtypes in breast cancers with gene expression profiling experiments. At least five molecular categories have been repeatedly identified in breast cancer, each with prognostic significance.
Methodology We retrospectively reported 18 cases of tripe negative cancer treated at salah azaiez institute Tunisia between 2016 and 2021.including 3 cases of CAK (adenoid cystic carcinoma), 10cases of CI-TNS-CM (medullary carcinoma) et 5 cases de CA (apocrine carcinoma).
Result(s)*The average age was 68 years. The mean tumor size was 37mm. In 15/18 cases the tumors were grade III SBR modified. Lymphatic emboli were observed in 4 cases/18. The Ki67 was on average 57%. Metastatic lymph nodes were identified in 4 cases out of 14 having had axillary dissection.
Conclusion*The prognostic value of classical pathological variables such as tumor grade, lymph node status, and tumor size, could be impaired in TNBC. Indeed, most TNBC are high grade, and first generation prognostic molecular assays, which are driven mainly by proliferation, did not show prognostic value in TNBC. In contrast, Ki67 stainings in TNBC have been suggested to carry prognostic information in some reports but not in others.8Small (cT1a/b) node-negative TNBC are potentially aggressive as well. Despite the abovementioned issues, the Nottingham Prognostic Index (NPI) has been reported to be useful in TNBC.
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