Introduction/Background*IVLBCL is a rare subtype of B-cell lymphoma characterised by the proliferation of malignant lymphocytes within vascular lumina in the absence of an extravascular tumour mass. Due to its aggressive nature, systemic disease is often present at the time of diagnosis.

Methodology This is a case report of a a 55-year-old Chilean woman who was referred for management of a large complex ovarian mass suspicious for an ovarian neoplasm. She underwent a staging laparotomy, including a total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy and appendicectomy. A large, haemorrhagic, torted left ovarian mass weighing 6kg was removed. The left ovarian cyst showed extensive haemorrhagic infarction related to previous torsion. However, on microscopic examination, the myometrium and endocervical mucosa showed numerous capillaries containing an intravascular population of large lymphoid cells with malignant cytologic atypia. Immunohistochemistry confirmed these cells were of B lymphocyte lineage, hence forming a diagnosis of intravascular large B-cell lymphoma (IVLBCL). Following referral to a haematological oncologist, a positron emission tomography (PET) scan found no other evidence of disease and our patient was recommended for surveillance.

Result(s)*10 cases have been reported in the uterus, most of which present with abnormal vaginal bleeding or non-specific constitutional symptoms. There is no standardised treatment of IVLBCL, but most cases of uterine IVLBCL have been treated with both surgery and chemotherapy, with variable outcomes.

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Abstract 685 Figure 1

Conclusion*There is no standardised treatment of IVLBCL, but most cases of uterine IVLBCL have been treated with both surgery and chemotherapy, with variable outcomes.