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516 Variables that predict nodal status of patients with early cervical cancer in the SUCCOR Cohort
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  1. A Berasaluce,
  2. N Martín-Calvo,
  3. E Chacon,
  4. F Boria,
  5. N Manzour and
  6. LM Chiva
  1. University of Navarra

Abstract

Introduction/Background*We aimed to identify the variables associated with higher odds of positive nodes in women in the SUCCOR study and describe both disease free survival and overall survival by nodal status in those women.

Methodology We used data from the SUCCOR study, a European multicentre study that collected retrospective information of 1272 women who underwent a radical hysterectomy by open or minimally invasive surgery for stage IB1 cervical cancer (FIGO 2009) between January 2013 and December 2014. After exclusions, the final sample included 1157 patients. Missing values were imputed with the median in quantitative variable and grouped in a new category in qualitative ones. We compared sociodemographic and clinical characteristics of patients by node status. We used Student’s t test for quantitative variables and Pearson’s chi squared test for qualitative ones. Variables with a p value below 0.05 in the univariate analyses were introduced in a logistic regression model with stepwise forward selection. Finally, we compared disease free survival and overall survival by nodal status using the Log-Rank test

Result(s)*We found that women with large tumours (>2 cm), linfovascular space invasion, parametrial invasion, postoperative complications or positive (or <2 mm free) margins in the tumour were more likely to have positive nodes In the multivariable adjusted model, the variables that independently predict higher odds of positive nodes were: large tumour size (OR: 1.8; 95% CI:1.18-2.78), linfovascular space invasion (OR: 5,34; 95% CI 3.31-8.61), parametrial invasion (OR: 5.10; 95% CI 2.23-11.67), positive margins in the tumour (OR: 2,44; 95% CI 1.18-5.06), and postoperative complications (OR: 2.22; 95% CI: 1.42-3.48). The survival analyses showed significant differences in both disease-free survival (p=0.007) and overall survival (p=0,011) between groups.

Conclusion*In the Succor cohort the presence of large tumour size, lymphovascular space invasion, parametrial invasion, positive margins in the tumour and postoperative complications were associated with the presence of positive lymph nodes and worse survival.

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