Introduction/Background*Most frequent borderline ovarian tumors are serous and mucinous subtypes. Clear Cell Borderline Ovarian Tumor (CCBOT) is one of the rarest subtypes of borderline ovarian malignancies. Very few are known about this subtype and most of reports concerns very short series or case reports. The aim of this study was to determine the prognosis of a series of CCBOT and to analyze data published in the literature about this rare disease.
Methodology A retrospective review of patients with CCBOT treated or referred to our institutions. A centralized histological review by a reference pathologist and data on the clinical characteristics, management and outcomes of patients were required for inclusion.
Nineteen patients were identified Median age was 62 (range 36-83) years. Four patients underwent a conservative surgery and a bilateral salpingo oophorectomy +/– hysterectomy (unknown in 1 case). One patient had bilateral tumor and all cases were a stage-I disease. All CCBOTs showed an adenofibromatous pattern. Stromal microinvasion was observed in 7 cases and intra-epithelial carcinoma in 2 cases. Endometriosis was histologically associated in one case. The median follow-up was 76 months (range 6 – 231 months). No recurrence occurred. Two patients died of intercurrent disease.
Conclusion*Peritoneal restaging surgery is not required, since all patients reported had stage-I disease. Fertility sparing surgery appears to be a safe alternative in young patients. Synchronous endometrial disorders with atypia are infrequent. Prognosis is generally excellent and long-term risk of recurrence is low. The 2 recurrences described in literature occurred in stage-IC diseases, highlighting the importance of avoiding perioperative rupture.
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