Article Text

Download PDFPDF

879 Krukenberg tumors: gastric cancer metastasis
  1. S Saidi and
  2. S Ghomari
  1. Medical Oncology Department – CHU Tlemcen Laboratoire Toxicomed. Department de Medecine. Universite dTlemcen, Tlemcen, Algeria


Introduction/Background*Krukenberg tumors (TK) are defined as bilateral ovarian metastases, they are rare and represent 1 to 2% of ovarian tumors. They are secondary to digestive tumors and mainly of gastric origin. Often detected at an advanced stage of the disease, the survival prognosis is poor despite chemotherapy, with or without surgical resection.

Methodology A retrospective study on the files of patients treated, in the Medical Oncology department -Tlemcen Hospital from 2010 to 2020, was realized.

The goal of our work is to determine the ovarian metastases frequency in the course of gastric cancers as well as the clinical and therapeutic characteristics of this secondary location.

Result(s)*Six cases have been reported. The mean age was 52 years [31, 66]. The gastric neoplasia was diagnosed by epigastralgia, deterioration of performance status, vomiting, anorexia and weight loss. The gastric endoscopy exploration revealed antral tumor in five patients and subcardial tumor in one case. The anatomo-pathologic study found a moderately differentiated gastric adenocarcinoma and the signet ring cell carcinoma (3/3).

A total gastrectomy with lymph node dissection was performed in three patients, one of whom was after perioperative chemotherapy.

Ovarian metastases were synchronous in four patients and metachronous in two patients after a free interval of 16 months and 30 months respectively. Ovarian metastases were bilateral and were revealed by abdomino-pelvic CT. Only one patient was operated, a total hysterectomy with bilateral oophorectomy was performed. Three patients received palliative chemotherapy. Only supportive care was offered in two patients.

Conclusion*Krukenberg tumors are rare. The diagnosis is facilitated by pelvic ultrasound performed as part of the assessment of the extension of a cancer of digestive or extra-digestive location. Advances in chemotherapy could improve the prognosis of these tumors, which remains bleak.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.