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  • 562 Overall survival rates and progression free survival in IDS vs PDS in advanced ovarian cancer patients in the university hospitals of Leicester

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Ovarian cancer
562 Overall survival rates and progression free survival in IDS vs PDS in advanced ovarian cancer patients in the university hospitals of Leicester
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  1. A Barakat,
  2. A Ismail,
  3. Q Davies and
  4. S Chattopadhyay
  1. University Hospitals of Leicester , Gynae-Oncology , Leicester, UK

Abstract

Introduction/Background*Surgery is known to be a prognostic factor in patients with advanced ovarian cancer. However, how does the overall survival rates compare in patients undergoing Interval debulking surgery versus primary debulking surgery.

Methodology A retrospective study was done involving 102 advanced ovarian cancer patients (FIGO stage 3c and 4) undergoing IDS and PDS in the UHL between January 2015 to January 2020. The number of patients recruited for the study were 57 and 45 patients undergoing interval debulking surgery (IDS) and primary debulking surgery (PDS) respectively. The objective of the study is to explore and compare the survival outcomes in both groups.

Result(s)*Advanced ovarian cancer patients undergoing IDS have 1-year, 3-year and 5-year overall survival rates of 94.7%, 49.2% and 36.9%, while those undergoing PDS have overall survival rates of 84.4%, 68.9% and 61.3% (p=0.081) generally.

The 1-year, 3-year and 5-year overall survival rates in FIGO stage 3c advanced ovarian cancer patients was significantly higher in the PDS group in contrast to IDS patients. In fact, the overall survival rates are 92.3%, 48.3% and 38.6% in patients who underwent IDS and 91.2%, 77.1% and 67.5% in patients who underwent PDS (p=0.019). This was in contrast to comparing overall survival rates in FIGO stage 4 where the two groups showed no statistical difference (p=0.726).

Furthermore, 1-year, 3-year and 5-year progression free survival was significantly higher (p=0.032) in patients who underwent PDS (77.8%, 35.8% and 26.9%) in comparison to patients who underwent IDS (61.4%, 21.1% and 13.2%).

Abstract 562 Figure 1
Abstract 562 Figure 1

Kaplan-Meier survival curve for overall survival with groups in total stage

View this table:
Abstract 562 Table 1

Kaplan-Meier survival curve for overall survival with groups in total stage

Abstract 562 Figure 2
Abstract 562 Figure 2

Kaplan-Meier survival curve for overall survival with groups in stage 3

View this table:
Abstract 562 Table 2

Kaplan-Meier survival curve for overall survival with groups in stage 3

Abstract 562 Figure 3
Abstract 562 Figure 3

Kaplan-Meier survival curve for progression free survival with groups

View this table:
Abstract 562 Table 3

Kaplan-Meier survival curve for progression free survival with groups

Conclusion*IDS and PDS effectiveness is stage dependent in advanced ovarian cancer patients.

https://doi.org/10.1136/ijgc-2021-ESGO.430

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