Introduction/Background*Cancer of the uterine corpus is the most common pelvic gynecologic malignancy in developed countries and has been reported to be on the increase in developed countries. However, there is a paucity of data on the trend of endometrial cancer in developing countries.

Methodology A 10-year review of endometrial malignancies (2011-2020) at a tertiary institution in Nigeria. Data on endometrial cancer were generated using a cancer registry (ICD-10 CanReg5 software). There were 93 endometrial malignancies during the period and data was analyzed using SPSS version 22

Result(s)*A total of 93 (100%) were analyzed. Most of the patients had tertiary education 51 (56.7% 54.8%). The peak age range was 60-69years (34%) followed by 50-59years (26%). However, 5 (5.4%) cases recorded were below the age of 40years. Approximately 65 (69.9%) cases of endometrial carcinomas were endometrioid adenocarcinomas. Other histologic subtypes include; adenosquamous 11 (11.8%), Papillary 8(8.6%) sarcomas 7 (7.5%), and 1 (1.1%) for clear cell type, and mixed Mullerian tumour respectively. The histological forms of the five (5.4%) recorded in under 40years patients were endometrioid adenocarcinoma 3 (60%) and adenosquamous 2 (40%). There was a sustained rise in the prevalence of endometrial cancer from 4 (4.3%) in 2016 to 21 (22.6%) in 2018 with a slight decline to 18 (19.4%) in 2019. However, in 2020 a sharp decline was recorded. The occurrence of endometrial cancer in the younger age group (below 40 years) was recorded during the period of the sudden rise in the prevalence of endometrial cancer.

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Abstract 1134 Figure 1

Trend of endometrial CA from 2011–2020

Conclusion*Given the increasing prevalence of endometrial cancer in our setting, there is a need for lifestyle modifications and increase awareness of endometrial cancer. More research efforts and aids are needed in other to curb the increasing trend of this problem in developing countries.