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1108 Implications of obesity in endometrial cancer
  1. MC Tirnovanu1;2,
  2. D Timofte3;4,
  3. R Corduneanu5,
  4. A Crudu5,
  5. B Scurtu5,
  6. A Iov6 and
  7. VG Tîrnovanu7
  1. 1University of Medicine and Pharmacy „Gr T Popa’ , Obstetrics and Gynecology, Iasi, Romania
  2. 2Clinical Hospital of Obstetrics and Gynecology „Cuza Vodă’ , Iasi, Romania
  3. 3University of Medicine and Pharmacy „Gr T Popa’ , Surgery, Iasi, Romania
  4. 4Clinical Hospital „Sfântul Spiridon’ Iaşi, Surgery, Iasi, Romania
  5. 5Clinical Hospital of Obstetrics and Gynecology „Cuza Vodă’ , Obstetrics and Gynecology, Iasi, Romania
  6. 6University of Medicine and Pharmacy „Gr T Popa’ , student sixth year, Iasi, Romania
  7. 7University of Medicine and Pharmacy „Gr T Popa’ , student fourth year, Iasi, Romania


Introduction/Background*Over half of the endometrial cancers (EC) are caused by obesity, known as an independent risk factor. In Romania, in the last years the obesity rate had an alarming growth, with many high grade cases that influence the clinical management of the disease, the surgical procedure, radiotherapy planning, and the survival rate. Objective: To establish the obesity incidence according to BMI (body mass index) in 1st Department of Gynecology Iasi and to correlate the grade of obesity with prognostic factors. We also looked at the challenges of treating EC caused by obesity.

Methodology It was a prospective study on 110 pacients with surgical treatment for EC from the 1st Clinic of Gynecology Iasi between January 2014-June 2021. We evaluated the BMI of the patients defined by WHO. For 15 women we made correlation between others parameters for assessing obesity and aggressiveness of EC.

Result(s)*The mean age of the patients was 60.15 years (limits 36-87 years). 83.33% of the cases were diagnosed with stage I cancer. 54 women were obese. Most of them associated hypertension with obesity-36, 27 cases had diabetes with obesity and only 25 women presented the classic triad hypertension-diabetes-obesity. We didn’t find statistic correlation between obesity rate and disease stage (p=0.427), tumor grading (p=0.690) or vascular invasion (p=0.84). 5 patients presented wound infection, 3 had dehiscent scar.

Conclusion*Obesity is involved in disease pathogeny but cancer aggressiveness is not correlated with the grade of it. The association between obesity and hypertension determines a more advanced stage of disease and increases the grading. The classical risk triad was not statistically influenced the stage p=0.580 and grading p=0.098. Weight loss after surgery is a priority for decreasing the rate of recurrence, but in our country few patients understand the importance of this goal.

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