Article Text

Download PDFPDF

931 Prognostic factors and survival outcomes of women with uterine leiomyosarcoma: A Turkish Uterine Sarcoma Group Study-003
  1. A Ayhan1,
  2. K Güngördük2,
  3. G Khatib3,
  4. Z Cüylan4,
  5. N Boran5,
  6. M Gokcu6,
  7. H Celik7,
  8. N Ozgul8,
  9. Ö Akbayır9,
  10. T Simsek10,
  11. A Bakay11,
  12. F Köse12,
  13. M Tunç1,
  14. Ü Küçükgöz3,
  15. S Koç5,
  16. E Kuscu1,
  17. MA Vardar3,
  18. H Akıllı1,
  19. C Taskiran13 and
  20. MM Meydanli14
  1. 1Baskent University, Turkey
  2. 2Mugla Sıtkı Kocman University, Turkey
  3. 3Çukurova University
  4. 4Ankara City Hospital
  5. 5Etlik Zubeyde Hanim Women’s Health Training and Research Hospital
  6. 6İzmir University of Economics Medicine Faculty Medical Park Hospital, Gynecological Oncology, İzmir, Turkey
  7. 7Başkent Üniversitesi Adana Uyg. ve Araşt. Merkezi Yüreğir Başkent Hastanesi, Turkey
  8. 8Hacettepe University
  9. 9Kanuni Sultan Süleyman Education and Research Hospital
  10. 10Akdeniz University
  11. 11Ondokuz Mayıs University
  12. 12Acıbadem University
  13. 13Koç University
  14. 14Zekai Tahir Burak Women’s Health Training and Research Hospital, Turkey


Introduction/Background*To assess the clinicopathological features, prognostic factors, and survival rates associated with uterine leiomyosarcoma (uLMS).

Methodology Databases from 15 participating gynecological oncology centers in Turkey were searched retrospectively for women who had been treated for stage I-IV uLMS between 1996 and 2018.

Result(s)*Of 302 consecutive women with uLMS, there were 234 patients with Federation of Gynecology and Obstetrics (FIGO) stage I disease and 68 with FIGO stage II-IV disease. All patients underwent total hysterectomy. Lymphadenectomy was performed in 161 (54.5%) cases. A total of 195 patients received adjuvant treatment. The 5-year disease-free survival (DFS) and overall survival (OS) rates were 42% and 54%, respectively. Presence of lymphovascular space invasion (LVSI), higher degree of nuclear atypia, and absence of lymphadenectomy were negatively correlated with DFS, while LVSI, mitotic count, higher degree of nuclear atypia, FIGO stage II-IV disease, and suboptimal surgery significantly decreased OS.

Conclusion*LVSI and higher degree of nuclear atypia appear to be prognostic indicators for uLMS. Lymphadenectomy seems to have a significant effect on DFS but not on OS.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.