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745 The clinical impact of MSI and dMMR in advanced endometrial cancer: the effect of online education on clinician knowledge, competence and confidence
  1. G Fisher1;2,
  2. A Furedy2,
  3. J Vandenbroucque2 and
  4. C Marth3
  1. 1Medscape Education Global, UK
  2. 2Medscape Education Global, London, UK
  3. 3Innsbruck Medical University, Innsbruck, Austria


Introduction/Background*This study determined whether online continuing medical education (CME) could improve the knowledge of obstetricians/gynaecologists (obs/gyns) and oncologists (oncs) regarding the relevance of Microsatellite Instability (MSI) and deficient Mismatch Repair (dMMR) for immunotherapy paradigms in advanced endometrial cancer, and increase competence in terms of the application of appropriate diagnostic testing.

Methodology A 15-minute online video discussion between two expert faculty was launched for physicians outside the USA October 2020 with data collected to March 2021. Educational effect assessed with repeated-pairs pre-/post-activity- individual participants serving as their own control. 3 multiple-choice, knowledge questions and 1 self-efficacy, 5-point Likert scale confidence question were analysed. McNemar’s test assessed pre- to post-activity change (5% significance level, P <.05). Magnitude of change in total number of correct responses overall, and for each question, determined with Cohen’s d (<.2=Modest, .20-.49=Small, .50-.79=Moderate, >.80=Large.

Result(s)*393 obs/gyns and 73 oncs completed pre- and post-activity questions. Positive educational effect was observed for obs/gyns (moderate effect, Cohen’s d=.78, P<.001; average% of correct responses increasing from 43 to 67%) and oncs (large effect, Cohen’s d=.88, P<.001; average% of correct responses increasing from 57 to 80%). Increases in correct responses post-activity were seen for questions on features of dMMR (% relative improvement, obs/gyn: 37%, oncs 25%), appropriate diagnostic testing (obs/gyns: 17%, oncs: 13%), and frequency of dMMR (obs/gyns: 188%, oncs: 133%). The% of participants answering all questions correctly increased from 7 to 30% for obs/gyns and from 16 to 53% for oncs. Pre-activity knowledge for both specialties was low on the features and frequency of dMMR and despite significant improvements, there remained room for improvement post-activity. Confidence in understanding the relevance of dMMR in advanced endometrial cancer increased post-activity with 63% of obs/gyn and 48% of oncs with improved confidence. Overall, 63% of obs/gyns and 60% of oncs improved their knowledge and competence by answering at least one more question correctly post-activity.

Conclusion*This on-demand, online video discussion resulted in a positive educational impact. However, education gaps remain evident. Online medical education is valuable in supporting the implementation of new diagnostic strategies into clinical practice as well as identifying areas of continued educational need.

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