Article Text

Download PDFPDF
Utilization and outcomes of sentinel lymph node biopsy in patients with early stage vulvar cancer
  1. Catherine E Hermann1,
  2. Dimitrios Nasioudis2,
  3. Spyridon A Mastroyannis2,
  4. Nawar A Latif2,
  5. Ashley F Haggerty2,
  6. Robert L Giuntoli II2,
  7. Lori Cory2,
  8. Sarah H Kim2,
  9. Mark A Morgan2 and
  10. Emily M Ko2
  1. 1 Pennsylvania Hospital OBGYN, Penn Medicine, Philadelphia, Pennsylvania, USA
  2. 2 Division of Gynecologic Oncology, Penn Medicine, Philadelphia, Pennsylvania, USA
  1. Correspondence to Dr Catherine E Hermann, Pennsylvania Hospital OBGYN, Penn Medicine, Philadelphia, Pennsylvania, USA; catherine.e.hermann{at}gmail.com

Abstract

Objective A retrospective cohort study comparing survival and perioperative outcomes of patients with early vulvar cancer who underwent sentinel lymph node biopsy versus standard lymphadenectomy

Methods Patients diagnosed between January 2012 and December 2015 with vulvar squamous cell carcinoma of less than 4 cm in size, with invasion of at least 1 mm, who underwent sentinel lymph node biopsy, lymphadenectomy, or both were identified from the National Cancer Database. Overall survival was evaluated following generation of Kaplan-Meier curves and compared with the log-rank test for patients who had at least 1 month of follow-up. A Cox model was constructed to control for confounders.

Results A total of 1583 patients were identified; 304 patients (19.2%) underwent sentinel lymph node biopsy alone. Sentinel lymph node biopsy utilization increased 13.9% between 2012 and 2015. Patients who underwent sentinel node biopsy alone were less likely to have comorbidities compared with those undergoing lymphadenectomy only or sentinel node biopsy with lymphadenectomy (25.3% vs 32.9% vs 31.9%, p=0.042), had smaller tumors (median 1.6 vs 2.0 vs 2.0 cm, p<0.001), and were less likely to have positive lymph nodes (11% vs 19.6% vs 28.1%, p<0.001). There was no difference in 3 year overall survival between the three groups (86.3% vs 82.1% vs 77.9%, p=0.26). After controlling for age, race, insurance, comorbidities, lymph node metastases, and tumor size, sentinel lymph node biopsy alone was not associated with worse overall survival compared with lymphadenectomy (HR 0.86, 95% CI 0.57 to 1.32). The sentinel node only group had shorter inpatient stays compared with lymphadenectomy only (median 1 vs 2 days, p<0.001) and a lower rate of unplanned readmission (1.7% vs 5.0%, p=0.010).

Conclusions The utilization of sentinel lymph node biopsy is increasing in the management of vulvar cancer and is associated with superior perioperative outcomes without impacting overall survival.

  • vulvar neoplasms
  • sentinel lymph node
View Full Text

Statistics from Altmetric.com

Footnotes

  • Contributors All of the authors listed have made substantial contributions to conceptualization and editing of the manuscript for intellectual content, and all authors have approved the final version submitted for publication.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests RG discloses a grant from AstraZeneca, however there was no relevance to this project. EMK discloses a grant from American Cancer Society and from Tesaro, also with no relevance to this project.

  • Patient consent for publication Not required.

  • Ethics approval The study was deemed exempt by the University of Pennsylvania Institutional Review Board (ID #829268).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon reasonable request. In accordance with the journal’s guidelines, we will provide our data for the reproducibility of this study in other centers if such is requested. The data is in deidentified form from the National Cancer Database.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.