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532 Fertility and pregnancy outcomes after fertility-sparing treatment in ovarian cancer patients
  1. Flavia Sorbi,
  2. Emanuele Arturo Fera,
  3. Roberto Domenico Cincotta,
  4. Fambrini Massimiliano,
  5. Irene Ladisa,
  6. Chiara Biagiotti,
  7. Francesca De Bonis,
  8. Rachele Gaddi and
  9. Maria Elisabetta Coccia
  1. Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Florence, Italy


Introduction/Background Incidence of ovarian cancer (OC) among reproductive-aged women has increased. Unlike cervical cancer, there are scanty recomandations on fertility-sparing treatment for OC.

The aim of this study is to evaluate fertility and obstetrics outcomes in patients with history of OC after fertility-sparing surgical treatment.

Methodology A prospective single-center study was performed on patients with stage I OC diagnosis made between January 2013 and December 2016 at the Careggi University Hospital in Florence. Data were collected with a telephone questionnaire in order to analyzed not only oncological outcomes but also fertility and pregnancy outcomes.

Results A total of sixteen patients with OC were enrolled. The average age of patients at diagnosis was 29 years, and twelve patients were nulliparous. Most of them (11 pts, 68,75%) had serous low-grade OC (LGOC), 12,5% high grade serous OC, 12,5% juvenile granulosa cell cáncer and one patient (6,25%) had mucinous LGCOS. There patients (18,5%) underwent adjuvant chemotherapy as their stage was IC. Mean follow-up was 63 months, OS rate was 100%, PFS at three year was 72,5%. Pregnancy outcomes were better among those patients who underwent ART (n=10), with 100% of pregnancy rate vs 75% the other six patients (p < 0.05), 4,10% of miscarriage rate vs 6,8% in no-ART group (p<0.05), and bith rate of 100% vs 83% in no-ART group (p<0.01). Concerning ovarian hormonal function, an FSH value > 40 mUI/ml was found in only one patient (6,25%) and an estradiol values < 20 pg/ml in a percentage of 18,5%. Turning to AMH value: all patients had AMH above 0,1 ng/ml, 3 patients (18,75%) had AMH between 0.1 and 1 ng/ml, 13 (81,25) patients had AMH values >1 ng/ml.

Conclusion Our study represents an analysis of the globally fertility in patients with OC. Pregnancy and fertility results following ART seems to be promising, though the reproductive outcome are significantly better when patients are sent to ART.

Disclosures The authors have no conflicts of interest to declare.

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