Article Text

Download PDFPDF

506 Oral metronomic cyclophosphamide in recurrent ovarian cancer: a single centre experience
  1. Daniela Attianese1,
  2. Enrico Badellino1,
  3. Michela Villa1,
  4. Marco Bellero2,
  5. Roberta Massobrio1,
  6. Nicoletta Biglia1 and
  7. Annamaria Ferrero1
  1. 1Mauriziano Hospital; Academic Department Gynaecology
  2. 2Mauriziano Hospital; Hospital Pharmacy


Introduction/Background Oral metronomic cyclophosphamide (OMC) consists in the chronic administration of low, usually daily, doses of chemotherapy. The effective reduction of tumour growth, oral administration, low toxicity profile and low cost benefit women with relapsed ovarian cancer, especially heavily pretreated patients. We retrospectively evaluated the outcome of patients treated with OMC for recurrent ovarian cancer.

Methodology We selected patients treated with OMC (50 mg daily) from 2016 to 2020 at the Academic Department Gynaecology, Mauriziano Hospital, Torino, Italy. Progression free survival (PSF) and toxicities profile were evaluated.

Results Thirty-five patients were analyzed. 28 (87%) had FIGO stage III and IV disease at diagnosis and 59% had received ≥ 4 previous lines. Average age was 68 years (range 47–88). Before starting OMC 16% had ECOG 0, 65% ECOG 1 and 19% ECOG 2. Median PFS was 5 months. PFS was ≥ 6 months in 33% of patients, ≥ 12 months in 13% and ≥ 18 months in 7%. 52% experienced clinical benefit in terms of symptoms reduction. 3% of discontinuation for side effects and no G3-4 hematological toxicities reflected a low toxicity profile. Only nausea and fatigue G1-G2 were reported in 4 (12%) and 9 (28%) cases, respectively.

Conclusion OMC could be a feasible alternative therapy for recurrent ovarian cancer leading to an acceptable clinical response with a low toxicity profile, even if patients are heavily pretreated and with a suboptimal performance status.

Disclosures Authors have no conflict of interest.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.