Introduction/Background The COVID-19 pandemic brings about various challenges for surgeons in different fields. They should assess the risk-benefit of each surgery prior to the operation, and decide whether the surgery is beneficial for the patient or the surgery is delayable due to the risk of COVID-19 infection. In this regard, gyneco-oncology surgeries are no exception. If the treatment is deferred, it may lead to the progression of the disease, affect the quality of life and patient’s survival.

Case Reports In this article, we report and discuss three cases of gynecologic cancer including two cases of endometrial cancer and one case of cervical cancer in situ that referred to Mahdiyeh hospital, Tehran, Iran, during the COVID-19 pandemic.

Conclusion According to the centers for disease control and prevention (CDC) guidelines, the COVID-19 Polymerase Chain Reaction (PCR) must be performed for each patient before surgery. If the patient was positive for COVID-19, the surgery should be postponed for at least two weeks. If the test is negative and the patient is candidate for surgery, delay in surgery should be minimized and efforts should be made to discharge the patient earlier to reduce the contact of patient with health worker and other patients. All of these processes are to protect the cancer patient from COVID-19 infection. For the current situation of COVID-19 pandemic, risk assessment should be done carefully to identify whether the role of surgery is curative or palliative and how it may impact the life expectancy of the patient. Every cancer patient should be screened for possible infection before the surgery. During the surgery, measures should be taken to reduce the time of surgery and complications that my lead to ICU (intensive care unit) admissions. Discharging patients earlier after the surgery could also reduce the risk of infection.

Disclosures There is not any conflict of interest to be declared regarding the manuscript.