Extrauterine choriocarcinoma in the fallopian tube is a rare but most aggressive genital malignancy. Accordingly, the diagnosis is difficult and often misdiagnosed. This case report presents a patient - the 33-year-old infertile female who received clomiphene for ovarian induction presented with complaints of intense pain in the lower abdomen. Her transvaginal sonography was suggestive of the right tubal ectopic pregnancy, and β-human chorionic gonadotropin (β-hCG) levels were remarkably high. The patient was diagnosed as ruptured tubal ectopic pregnancy, and laparoscopic right salpingectomy was performed. Histological analysis was suggestive of tubal choriocarcinoma. Immunohistochemistry tests were positive for AE1/AE3, inhibin, hCG, EMA, Ki67, and negative for p63, accordingly supporting the diagnosis of choriocarcinoma. The patient was treated with chemotherapy and is being followed up by β-hCG monitoring. Our aim in presenting this case is to emphasize the importance of histopathological examination of the tubal specimens in every patient who presents with an ectopic pregnancy to rule out the possibility of tubal choriocarcinoma. Especially, histopathology diagnosis and appropriate β-hCG monitoring are crucial, since this is extremely rare and highly malignant pathology, is otherwise curable in most instances.
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