Introduction Breast cancer is the most common malignancy in women around the world. In the Cap Bon, the epidemiological features of breast cancer are unknown.

We aim to identify the epidemiological, clinical, and histological characteristics of breast cancer in the Cap Bon.

Methods A retrospective study of 130 patients diagnosed with breast cancer from January 2014 to December 2017 and treated in Mohamed Taher Maamouri Hospital of Nabeul, Tunisia.

Results Five patients (3.8%) were male. The average age was 55.7 years. The young women (≤35 years) represented 4.6%. Stage T2 was predominantly observed (48.8%). The tumors were classified as N1 in 54.2% of cases. Four patients (3%) had Metastasis. The infiltrating ductal carcinoma was the most common histological type (80%). The average histological size was 27.7 mm. The most common molecular subtype was Luminal B (48%). The nodes were positive in 57.4% of cases. All the patients had breast surgery. It was conservative in 40% of cases. Radiotherapy was performed in 87.3% of cases. The chemotherapy was administrated to 73.8% of patients. The trastuzumab was administered to 76.4% of the patients. Hormonotherapy was administered to 90.3% of patients. Overall survival and progression-free survival at 3 years were 90% and 73.2% respectively. Prognostic factors were the N stage and the lymph node involvement.

Conclusion The epidemiological characteristics of breast cancer in the Cap Bon present a number of similarities to the other regions of the country. However, it differs from the high frequency of pejorative histoprognostic factors.