Article Text

Download PDFPDF

12 Oncolytic vaccinia (Olvi-Vec) primed immunochemotherapy in platinum-resistant/refractory ovarian cancer
  1. R Holloway1,
  2. A Mendivil2,
  3. J Kendrick1,
  4. L Abaid2,
  5. J Brown2,
  6. C Fitzsimmons1,
  7. J Kennard1,
  8. M King2,
  9. J LeBlanc1,
  10. K Lopez2,
  11. M Manyam1,
  12. N McKenzie1,
  13. K Mori2,
  14. A Stephens1 and
  15. S Ahmad1
  1. 1AdventHealth Cancer Institute, USA
  2. 2Gynecologic Oncology Associates, USA


Introduction Intraperitoneal oncolytic vaccinia virus (Olvi-Vec) was administered to heavily pretreated patients with platinum-resistant/refractory ovarian cancer (PRROC) followed by intravenous carboplatin-doublet (CD) ± bevacizumab (Bev) in a Phase-2 trial (NCT02759588). Primary objectives: RECIST overall response rate (ORR) & progression-free survival (PFS).

Methods Patients with PRROC who progressed after most recent therapies received 2 days of Olvi-Vec followed by CD±Bev, then maintenance with single-agent therapies ± Bev. Pre-&post-virotherapy tumor biopsies were obtained for translational analyses.

Results 27 patients enrolled: median 4 prior regimens, 82% prior Bev, 52% platinum-refractory and 48% platinum-resistant. Mean cycles of CD±Bev were 6(±3). Median follow-up was 26.5 months. RECIST ORR was 54% (95%CI:33–74%): 2(8%) complete response, 11(46%) partial response; 8(33%) stable disease. Median duration of response was 7.6 months (95%CI:3.7–9.6). Clinical benefit rate was 88%. Median PFS was 11.0 months (95%CI:6.7–13.0), and PFS-6-month was 77%. CA-125 ORR was 85% (95%CI:65–96%). There were no Grade 4 adverse events with virotherapy. Performance status was preserved/improved in 24 (89%) patients while on CD±Bev. Post-virotherapy intra-tumoral infiltration of CD8+ T-cells and upregulation of STAT1 expression (p=0.008) were demonstrated.

Abstract 12 Table 1

Baseline characteristics

Conclusions Despite PRROC, prior bevacizumab, and progression on last therapy, the majority of patients achieved RECIST response with median PFS exceeding their prior line of therapy. Virus-induced changes in the tumor microenvironment may explain the apparent clinical reversal of platinum resistance.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.