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202 Effects of radiological and pathological lymph node status on prognosis in patients with ovarian cancer who underwent interval debulking surgery with lymphadenectomy after neoadjuvant chemotherapy
  1. H Komatsu,
  2. Y Iida,
  3. D Osaku,
  4. R Shimogai,
  5. J Chikumi,
  6. S Sato,
  7. T Oishi and
  8. T Harada
  1. Tottori university, Japan


Objectives We aimed to analyze whether radiological and pathological lymph node status affected the prognosis in patients with epithelial ovarian cancer who underwent neoadjuvant chemotherapy (NAC) followed by interval debulking surgery (IDS).

Methods A total of 82 patients who had undergone IDS, including systematic retroperitoneal lymphadenectomy, at Tottori University Hospital were eligible for this study. We retrospectively analyzed the association of lymphadenopathy before (rLN) and after (yrLN) NAC, pathologically confirmed lymph node metastasis (pLN), and prognosis. The patient survival distribution was calculated using the Kaplan-Meier method.

Results Of the 82 cases, 36 were rLN+ (43.9%), 10 were yrLN+ (12.1%), and 39 were pLN+ (47.5%). No significant differences in progression-free survival (PFS) and overall survival (OS) were observed between rLN+ and rLN- patients. The PFS and OS in yrLN+ patients were not different from those in the yrLN- patients. Both the PFS and OS were significantly shorter in pLN+ patients compared to pLN- patients (p < 0.001 and p = 0.004, respectively). Univariate analysis revealed that FIGO stage, pLN, and an absence of gross residual disease were prognostic factors for PFS and OS. Multivariate analysis revealed that pLN was an independent prognostic factor for PFS (p = 0.001) and that pLN and an absence of gross residual disease were independent prognostic factors for OS (p = 0.046, p = 0.012).

Conclusion Only the pathological lymph node status affected PFS and OS in patients with ovarian cancer who underwent NAC followed by IDS, whereas the radiological lymph node status may not be a prognostic factor in such patients.

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