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144 Ovarian carcinoma long-term survivors: a large single center study at the tübingen university women’s hospital
  1. S Mittelstadt1,
  2. M Grube1,
  3. T Engler1,
  4. CB Walter1,
  5. E Oberlechner1,
  6. J Pasternak1,
  7. U Hurst1,
  8. B Krämer1,
  9. E Grischke1,
  10. SY Brucker1,
  11. AK Fischer2,
  12. A Staebler2,
  13. A Hartkopf1 and
  14. S Kommoss1
  1. 1Department of Women’s Health, Tübingen University Hospital, Germany
  2. 2Department of Pathology and Neuropathology, Tübingen University Hospital, Germany


Introduction/Objectives Most ovarian carcinoma patients present with advanced-stage disease and outcome is fatal in many cases. However, the biological behavior of ovarian carcinoma can be quite variable and long-term survival is reported in up to 30% of patients. It is the aim of this project to identify characteristics associated with long-term survival.

Methods Patients diagnosed with ovarian carcinoma between 2000 and 2012 were identified and follow-up data was collected. In patients who survived for at least 8 years a detailed chart review was performed.

Results A total of n=749 patients with adequate follow-up was identified, of which n=225 (29%) were alive for at least 8 years after diagnosis. Median follow-up was 11.7 years. Median age at diagnosis was 53.5 years. 57% were diagnosed in advanced stage (≥FIGO IIB). Histotyp was found to be high-grade serous in 53%, low-grade serous in 7.9%, mucinous in 7.4%, clear cell in 3.7% and endometrioid in 20% of patients. Median progression free survival was 5.0 years in early, and 2.8 years in advanced-stage patients.

Conclusion Despite ovarian carcinoma being perceived as a highly fatal disease, long-term survival is observed in a substantial number of patients and is not limited to early-stage or low-risk disease. Although prognostic factors are well established, further research of patient characteristics, genetic features and treatment modalities will help to better understand factors contributing to long-term survival. We encourage the scientific community to be aware of this special patient group, which may be key to improving our daily approach to ovarian carcinoma patients.

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