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131 The increasing racial disparity of uterine carcinosarcoma over 16 years: a study of 35,000 patients
  1. C Liao1,
  2. M Richardson2,
  3. K Tran2,
  4. C Chan3,
  5. AK Mann3,
  6. GL Maxwell4,
  7. CA Hamilton5,
  8. C Tian4,
  9. KM Darcy4,
  10. DS Kapp6 and
  11. JK Chan3
  1. 1Kaohsiung Veterans General Hospital, Taiwan
  2. 2University of California Los Angeles, USA
  3. 3Palo Alto Medical Foundation, California Pacific Medical Center, Sutter Health, USA
  4. 4Walter Reed National Military Medical Center, USA
  5. 5Inova Schar Cancer Institute, USA
  6. 6Stanford University School of Medicine, USA


Objective To evaluate the racial disparities of uterine carcinosarcoma based on incidence and trends in the United States.

Methods From 2001 to 2016, incidence rates were estimated from the United States Cancer Statistics after correcting for hysterectomy and pregnancy prevalence from the Behavioral Risk Factor Surveillance System (BRFSS). SEER*Stat and Joinpoint regression were used to calculate the incidence rate (per 100,000) and average annual percent change (AAPC).

Results Of 35,524 patients with carcinosarcoma, 66% were White, 24% Black, 7% Hispanic, and 3% Asian. Between 2001 and 2016, the overall incidence increased from 2.7 to 3.5, with an average annual percent change (AAPC) of 1.5% (p<0.001). Black women had a 3 fold higher incidence at 9.9 per 100,000 compared to 2.8 in Whites. Additionally, Black women had a higher annual increase at 2.4% vs. 1.1% in Whites. With respect to age, patients aged 75–79 had the highest incidence at 15.5. To identify a group of patients at highest risk using demographic factors, we found the intersectionality of Blacks aged 70–74 years had an incidence of 43.2/100,000 with an increase of 2.2% annually (p<0.001).

Conclusion Black women had a 3.5-fold higher incidence of uterine carcinosarcoma as compared to Whites. The rate of carcinosarcoma diagnosis is increasing for higher-risk populations, such as Black and older women.

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