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Persistent postoperative ascites successfully identified and treated with laparoscopic indocyanine green fluorescence
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  1. Rodrigo Fernandes1,
  2. Cristina Anton1,
  3. Andre Lopes1,
  4. Alexandre Silva e Silva1,
  5. Eric Leblanc2,
  6. Ulysses Ribeiro Jr3 and
  7. Jesus Paula Carvalho1
  1. 1 Obstetricia e Ginecologia, Universidade de Sao Paulo Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, Brazil
  2. 2 Gynecology Oncology, Oscar Lambret Cancer Centre, Lille, Hauts-de-France, France
  3. 3 Gastroenterologia, Universidade de Sao Paulo Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, São Paulo, Brazil
  1. Correspondence to Rodrigo Fernandes, Obstetricia e Ginecologia, Universidade de Sao Paulo Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, Brazil; ropfernandes{at}gmail.com

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Lymphatic ascites after a lymphadenectomy due to disruption of lymphatic vessels is a complication reported to happen in 2.7% of those procedures.1–3 There are several types of lymphatic leakage reported in the literature such as lymphorrhea, lymphocele, lymphatic ascites, chylous ascites, and lymphatic fistula. Medical treatment is the primary treatment of choice and has been reported to cure ascites in 66% to 77% of cases.1 Surgical treatment to identify the leakage site should not be considered as the first choice and is reserved if medical treatment fails to solve it.1 4 Indocyanine green (ICG) and fluorescence imaging (FI) have been vastly used for different purposes including sentinel lymph node identification for different types of cancer, retina evaluation, and organ perfusion before resection. In addition, ICG and FI have potential to solve contemporary problems in gynecologic oncology and may be used to evaluate perfusion of colorectal anastomosis or uterine perfusion after radical trachelectomy.5 6 In this video we present a case where ICG and FI were used to help identify the precise site of lymphatic leakage and successfully solve it. Different from previous authors who published ICG interdigital foot injection, we demonstrate an alternative application at the proximal part of the thigh.7

A 59-year-old woman diagnosed with high-grade serous ovarian carcinoma FIGO stage IIIC, underwent upfront debulking surgery with total hysterectomy, bilateral adnexectomy, omentectomy, and partial lymphadenectomy in another hospital.

The patient was referred to our institution and underwent six cycles of chemotherapy with carboplatin-paclitaxel, however she persisted with enlarged pelvic and para-aortic lymph nodes, suspicious for secondary involvement without any other sites of metastasis. We decided to perform systematic pelvic and para-aortic lymphadenectomy. A few days after the surgery the patient developed ascites confirmed by the clinical aspect and biochemical evaluation of the fluid.

Conservative treatment consisting of parenteral nutrition, a low-fat diet with medium-chain triglycerides, and several percutaneous drainages were unsuccessful. Then we decided to perform laparoscopy, ICG, and FI to fix the leakage.

During the procedure 1.2 liters of lymphatic ascites were drained. An injection of 1 mL of ICG in three sites of the proximal part of both thighs was performed and after 10 min the use of near infrared fluorescence successfully identified the active leakage site. Several metal clips were used to stop the leakage.

After surgery the patient was discharged with no further complications. Long-term follow-up demonstrated no more ascites.

The use of laparoscopy and ICG subcutaneous injection appears as a promising technique to identify active lymphatic leakage and treat it surgically. The injection of ICG to the thigh appears to be an alternative to interdigital foot injection.

Video 1.

References

Footnotes

  • Twitter @andrelopesMD

  • Correction notice Since the online publication of this article, the twitter handle for Andre Lopes was updated to @andrelopesMD

  • Contributors RPF (corresponding author): Surgeon, development of paper, review of the literature. CA: Surgeon, development of paper, review of the literature. AL: Development of paper. UR: Review of paper. EL: Development and review of paper. JPC: Development and review of paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial, or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available in a public, open access repository

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