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Technetium-99m-indocyanine green versus technetium-99m-methylene blue for sentinel lymph node biopsy in early-stage endometrial cancer
  1. Silvia Cabrera1,2,
  2. Vicente Bebia1,
  3. Silvia Franco-Camps1,
  4. Cristina Forcada1,
  5. Diego Villasboas-Rosciolesi3,
  6. Ignacio Navales3,
  7. Assumpció Pérez-Benavente1 and
  8. Antonio Gil-Moreno1,2
  1. 1 Gynecologic Oncology Unit, Gynecology Department, Hospital Universitari Vall d’Hebron, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain
  2. 2 Universitat Autònoma de Barcelona, Barcelona, Spain
  3. 3 Nuclear Medicine Department, Institut de Diagnòstic per Ia Imatge, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain
  1. Correspondence to Dr Silvia Cabrera, Gynecologic Oncology Unit, Gynecology Department, Hospital Universitari Vall d’Hebron, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; scabrera{at}vhebron.net

Abstract

Introduction The low accuracy of pre-operative imaging techniques for prediction of nodal status strengthens the relevance of sentinel lymph node (SLN) biopsy in endometrial cancer, although the optimal method for its detection is still under investigation. The increasing use of indocyanine green (ICG) has aroused concern about its enhanced visualization of lymphatic channels, which could lead to a specimen that is thought to be nodal tissue not subsequently yielding a lymph node on pathologic analysis ('empty node packet'). Our main objective was to compare the overall and bilateral detection rates for SLN biopsy using two combined techniques: technetium-99m-ICG (Tc-99m-ICG) versus technetium-99m-methylene blue (Tc-99m-MB). Our secondary aim was to compare the ‘empty node packet’ rates between the two cohorts.

Methods A prospective, non-randomized, single-center trial including patients diagnosed with endometrial cancer (any grade or histology) in pre-operative early stage, and operated on between February 2017 and July 2019. All tracers were injected intracervically. Pelvic and aortic lymphadenectomy were performed on patients at intermediate or high risk of recurrence pre-operatively. All SLNs were sent for intra-operative frozen section and afterwards processed following an ultrastaging protocol.

Results Eighty-four patients were included, 58% (n=49) in the Tc-99m-MB group and 42% (n=35) in the Tc-99m-ICG group. Overall detection rate was 93% and was not statistically different between the two groups. A better bilateral detection rate was observed among Tc-99m-ICG patients (69% vs 41%, p=0.012). The 'empty node packet' rate was 4% in the Tc-99m-ICG cohort and 0% in the Tc-99m-MB cohort (p=0.032).

Discussion Tc-99m-ICG is a feasible, safe technique for SLN biopsy in early-stage endometrial cancer, and appears to be superior in terms of bilateral detection to Tc-99m-MB. The addition of Tc-99m to ICG could decrease the rate of 'empty node packets' and better define the anatomic location of SLNs in patients with endometrial cancer.

  • sentinel lymph node
  • surgical oncology
  • endometrial neoplasms
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Footnotes

  • Editor's note This paper will feature in a special issue on sentinel lymph node mapping in 2020.

  • Contributors SC is the principal investigator, designed the study, reviewed the literature, collected and analyzed data, and wrote the paper. VB, SF, and CF contributed to the collection of data, critical revision of the manuscript, and read and approved the final draft. VB performed the statistical analyses. DVR and IN performed the nuclear medicine studies, reviewed the manuscript, and approved the final draft. APB and AGM reviewed the manuscript for intellectual and scientific content, and approved the final draft.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval Comité Ético de Investigación Clínica Y Comisión de Proyectos de Investigación del Hospital Universitari Vall d’Hebron, ID: PR(AMI)389/2016.

  • Provenance and peer review Commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article; more information related to this work is available upon reasonable request to the corresponding author.

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