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External validation of a 'response score' after neoadjuvant chemotherapy in patients with high-grade serous ovarian carcinoma with complete clinical response
  1. Pier Carlo Zorzato1,
  2. Gian Franco Zannoni2,
  3. Riccardo Tudisco3,
  4. Tina Pasciuto4,
  5. Andrea Di Giorgio5,
  6. Massimo Franchi6,
  7. Giovanni Scambia7 and
  8. Anna Fagotti7
  1. 1 Department of Obstetrics and Gynecology, Ospedale degli Infermi, Ponderano (BI), Biella, Italy
  2. 2 Fondazione Policlinico Universitario A. Gemelli IRCCS, Pathology Division, Department of Woman, Child and Public Health, Rome, Italy
  3. 3 Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy
  4. 4 Fondazione Policlinico Universitario A. Gemelli IRCCS, Statistics Technology Archiving Research (STAR) Center, Department of Woman, Child and Public Health, Rome, Italy
  5. 5 Fondazione Policlinico Universitario A. Gemelli IRCCS, Division of Peritoneal and Retroperitoneal Surgery, Rome, Italy
  6. 6 Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, Verona, Italy
  7. 7 Dipartimento Scienze della Salute della Donna e del Bambino, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
  1. Correspondence to Professor Giovanni Scambia, Dipartimento Scienze della Salute della Donna e del Bambino, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma 8 00168, Italy; giovanni.scambia{at}policlinicogemelli.it

Abstract

Objectives The chemotherapy response score (CRS) has been developed for measuring response to neoadjuvant chemotherapy in tubo-ovarian high-grade serous carcinoma. This study aimed to validate the ability of this three-tier scoring system of pathologic response on omental specimens to determine prognosis in a subgroups of patients who had clinical complete response to neoadjuvant chemotherapy.

Methods This was a retrospective study, conducted in women receiving interval debulking surgery at the Division of Gynecologic Oncology, between December 2007 and April 2017. Inclusion criteria were: high-grade serous ovarian cancer, FIGO stage IIIC/IV, platinum-based neoadjuvant chemotherapy, and clinical complete response after neoadjuvant chemotherapy (normalization in CA125 levels, disappearance of all target and non-target lesions according to RECIST 1.1). CRS was defined by a single pathology review and classified as previously reported: CRS1, no or minimal tumor response with fibroinflammatory changes limited to a few foci ranging from multifocal or diffuse regression-associated fibroinflammatory changes with viable tumor in sheets, or nodules to extensive regression-associated fibroinflammatory changes with multifocal residual tumor; CRS2, appreciable tumor response with viable tumor readily identifiable; and CRS3, complete absence of tumor or nodules with maximum size of 2 mm. CRS was analyzed according to clinical variables and survival.

Results A total of 108 patients were eligible for analysis. The average age was 65 (range 36–85) years. A total of 91 (84.3%) patients had stage IIIC disease and 17 (15.7%) patients had stage IV disease. No statistically significant differences were observed in terms of age, FIGO stage, CA125 serum levels, type of chemotherapy schedules, and number of cycles between the three groups. Patients in the CRS3 group had a longer median progression-free survival (25.8 months) compared with CRS2 or CRS 1 (20.3 vs 17.4 months, respectively; p=0.001). Median overall survival was 68.9 months for CRS3, 35.0 months for CRS2, and 45.9 months for CRS1 (p=0.034).

Conclusion Complete or near-complete pathologic response assessed in the omental specimens of advanced epithelial ovarian carcinoma patients after neoadjuvant chemotherapy (CRS3) is predictive of prolonged progression-free and overall survival. In particular, this is true in women with a clinical complete response.

  • ovarian cancer
  • surgical oncology
  • omentum
  • pathology
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Footnotes

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  • Contributors ZPC: study conception/design; data collection; data analysis/interpretation; manuscript preparation. ZGF: study conception/design; data analysis/interpretation. TR: data collection; data analysis/interpretation. PT: data collection; data analysis/interpretation; statistical analysis. DGA: responsible surgeon or imager; patient recruitment. FM: responsible surgeon or imager; patient recruitment. SG: responsible surgeon or imager; patient recruitment. FA: study conception/design; data analysis/interpretation; responsible surgeon or imager; manuscript preparation; patient recruitment.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon reasonable request.

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