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Extraperitoneal metastases after intraperitoneal chemotherapy of ovarian cancer patients with a negative second-look laparotomy
  1. J. Menczer,
  2. G. Ben-Baruch,
  3. S. Rizel* and
  4. H. Brenner*
  1. * Department of Obstetrics and Gynecology and Oncology, The Chaim Sheba Medical Center, Tel Hashomer, Affiliated to the Sackler School of Medicine, Tel Aviv University, Israel
  1. Address for correspondence: J. Menczer, MD, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer 52621, Israel.


The site of the first detectable recurrence was recorded in 17 consecutive stage II–IV ovarian carcinoma patients who, after a negative second-look laparotomy, received intraperitoneal chemotherapy with cisplatin and thiosulfate kidney protection. Although the progression-free interval and survival were favorable, 11 patients eventually had a recurrence and in six (54.5%) of these it was extraperitoneal. Brain metastases were detected in three patients. The appearance of extraperitoneal metastases is not always ominous.

  • extraperitoneal metastases
  • intraperitoneal chemotherapy
  • negative second-look laparotomy
  • ovarian cancer.

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