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The assessment of proliferating cell nuclear antigen (PCNA) immunostaining in the uterine cervix and cervical squamous neoplasia
  1. A. I. AL-NAFUSSI,
  2. H. S. KLYS,
  3. G. REBELLO,
  4. C. KELLY,
  5. G. KERR and
  6. V. COWIE
  1. Department of Pathology, University of Edinburgh, Teviot Place, Edinburgh, UK
  1. Address for correspondence: A. I. Al-Nafussi, Department of Pathology, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.


This is a retrospective study, in which PC10, a monoclonal antibody against proliferating cell nuclear antigen (PCNA) was used in the assessment of 20 cases of FIGO stage IB cervical carcinoma, 30 cases of CIN, 10 cases of koilocytosis and 20 cases in which the transformation zone was histologically normal. The results showed that in the normal transformation zone the proliferative compartment was confined to the first 1–2 suprabasal cell layers. In CIN the pattern of staining corresponded to the grade of the lesion. In viral wart lesions occasional koilocytes demonstrated strong nuclear staining. In all cases of stage IB cervical carcinoma the PC10 index was high, irrespective of tumor grade response to treatment.

  • PCNA (proliferating cell nuclear antigen)
  • squamous neoplasia
  • uterine cervix
  • viral wart

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