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Type I and Type II estrogen and progesterone binding sites in endometrial carcinomas: their value in predicting survival
  1. C. H. Buckley,
  2. H. Fox and
  3. E. Sivridis*
  1. Department of Pathological Sciences, University of Manchester and Department of Reproductive Pathology, St Mary's Hospital, Manchester, UK
  2. * Present address: Department of Pathology, Democritean University of Thrace, Alexandropolis, Greece.
  1. Address for correspondence: Professor H. Fox, MD, Department of Pathological Sciences, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK.


A simple and inexpensive immunocytochemical technique has been used to demonstrate estrogen (EB) and progesterone binding sites (PB) in endometrial carcinoma. Tumors were considered as being ‘binding-site’ rich if more than 40% of the component epithelial cells were positive for hormone binding sites (HB). By this criterion, over half of the adenocarcinomas studied were HB rich. Significantly higher 5- and 10-year survival rates were found in women whose tumors were HB rich compared with those whose neoplasms were HB poor, and a similar trend was established for patients with a combined EB rich/PB rich status versus that of EB poor/EB poor. This beneficial effect of a rich Type I and Type II receptor site status on survival, however, was shown only to a limited extent for EB. These results were independent of adjuvant treatment and of all clinical and histopathological features of known prognostic importance, save tumor differentiation. It is concluded that the immunocytochemical determination of HB status in formalin-fixed paraffin-embedded tissues adds significantly to the prognostic information available for endometrial adenocarcinoma.

  • adenocarcinoma
  • binding sites
  • endometrium
  • estrogen receptor
  • progesterone receptor
  • prognosis.

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