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Lympho-vascular space invasion is strongly associated with lymph node metastases and decreased survival in endometrioid endometrial cancer: a swedish gynecologic cancer group (SweGCG) study
  1. K Stålberg1,
  2. M Bjurberg2,
  3. C Borgfeldt3,
  4. J Carlson4,
  5. P Dahm Kähler5,
  6. A Flöter-Rådestad6,
  7. K Hellman4,
  8. E Hjerpe4,
  9. E Holmberg7,
  10. P Kjølhede8,
  11. J Marcickiewicz9,
  12. P Rosenberg10,
  13. B Tholander11,
  14. E Åvall-Lundqvist12 and
  15. T Högberg13
  1. 1Department of Women’s and Children’ Health, Uppsala University, Uppsala
  2. 2Department of Clinical Sciences, Lunds University
  3. 3Department of Obstetrics and Gynecology, Lund University, Lund
  4. 4Department for Oncology and Pathology, Karolinska Institutet, Stockholm
  5. 5Department of Obstetrics and Gynecology, Sahlgrenska Academy at University of Gothenburg, Gothenburg
  6. 6Department of Obstetrics and Gynecology, Karolinska Institutet, Stockholm
  7. 7Regional Cancer Center Western, Sahlgrenska University Hospital, Gothenburg
  8. 8Department of Children and Women’s Health, Linköpings University, Linköping
  9. 9Department of Obstetrics and Gynecology, Hallands Hospital, Varberg
  10. 10Linköping University, Department of Clinical Oncology and Department of Clinical and Experimental Medicine, Linköping
  11. 11Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala
  12. 12Department of Clinical Oncology and Department of Clinical and Experimental Medicine, Linköpings University, Linköping
  13. 13Department of Cancer Epidemiology, Lund University, Lund, Sweden


Introduction/Background The aim of this study was to evaluate the impact of lymphovascular space invasion (LVSI) on the risk of lymph node metastases and survival in endometrioid endometrial adenocarcinoma.

Methodology This is a retrospective cohort study based on prospectively recorded data. Patients with endometrioid adenocarcinoma registered in the Swedish Quality Registry for Gynecologic Cancer 2010–2017 with FIGO stages I-III and verified nodal status were identified (n=1587). LVSI together with DNA ploidy, FIGO grade, myometrial invasion and age, were included in multivariable regression analyses with lymph node metastases as the dependent variable. Associations between the risk factors and overall and relative survival were included in multivariable models. Estimates of risk ratios (RR), hazard ratios (HR), excess mortality rate ratios (EMR), and 95% confidence intervals (95% CI) were calculated.

Results The presence of LVSI presented the strongest association with lymph node metastases (RR=5.46, CI 3.69–8.07, p<0.001) followed by deep myometrial invasion (RR=1.64, CI 1.13–2.37, p=0.008). In the multivariable survival analyses, LVSI (EMR=7.69, CI 2.03–29.10, p=0.003) and non-diploidy (EMR=3.23, CI 1.25–8.41, p=0.016) were associated with decreased relative survival. In sub-analyses including only patients with complete para-aortic and pelvic lymphadenectomy and negative lymph nodes (n=404), only LVSI (HR=2.50, CI 1.05–5.98, p=0.039) was associated with a worsened overall survival.

Conclusion This large nationwide study identified LVSI as the strongest independent risk factor for lymph node metastases and decreased survival in patients with endometrioid adenocarcinomas. Moreover, decreased overall survival was also seen in patients with LVSI-positive tumors and negative lymph nodes, indicating that hematogenous dissemination might also be important.

Disclosure Nothing to disclose.

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