Introduction/Background Treatment of patients with vulvar carcinoma is challenging for oncologists, owning to the low incidence of the disease and the poor level of evidence for different treatment modalities.
Methodology This is a retrospective study involving patients with pathologically proven vulvar carcinoma, who presented to the National Cancer Institute, Cairo University during the period from January 2001 to December 2016.
Data was retrieved from the patients' medical records. The collected data included the patients' names, age, menopausal status, comorbidities, obstetric history, performance status, pathological subtype, FIGO stage, grade, date and type of surgery, details of adjuvant treatment and response to treatment, side effects and complications of treatment, follow-up details and patterns of failure, salvage treatment and patient status at last follow up.
Results This study highlights and confirms the data stating that lymph node status is the most important predictor for outcome of patients with carcinoma of vulva and also confirms that <2 lymph nodes have a better OS and DFS than patients ≥ 2 positive lymph nodes.
Postoperative radiotherapy significantly improved survival for patients who underwent surgical resection which was statistically significant.
It shows that tumor size at a cut-off value of ≤ 5 cm had better OS than patients with tumors >5 cm which was statistically significant.
Old age had significantly worse survival at a cut-off value of ≤ 69 years.
Conclusion patients with <2 positive lymph nodes had better OS than patients ≥ 2 positive lymph nodes, lack of prognostic significance of 2009 FIGO staging system should be studied carefully in larger studies in the future, also this study calls considering to include tumor size in staging system for cancer vulva, and downstage the patients with one positive lymph node.
Disclosure Nothing to disclose
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