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EP1137 Primary gestational choriocarcinoma of the uterine cervix and fallopian tube: the diagnosis of ectopic pregnancy is not always a benign condition
  1. E Karaman1,
  2. A Kolusarı1,
  3. I Alkış1,
  4. O Karaaslan2,
  5. HG Şahin2 and
  6. A Gül2
  1. 1Gynecologic Oncology
  2. 2Obstetric and Gynecology, Yuzuncu Yil University, Van, Turkey


Introduction/Background Choriocarcinoma is the most aggressive, malignant form of gestational trophoblastic disease. The most common localization is uterus. However, in some cases, it can be found in cervix, tuba uterina or ovaries. Here, we present two different clinical cases of which were misdiagnosed as ectopic pregnancy.

Methodology A 36 year-old patient admitted to our department for investigation of irregular vaginal bleeding. On ultrasound examination, the endometrial line was thin and bilateral adnexial structures were normal. B-hcg level was 2815 mIU/L, progesteron was 0.2. On B-hcg follow-up, the levels were 2764 and 2877 at two days intervals. The patient was given methotrexate for the diagnosis of ectopic pregnancy. One week later, B-hcg level increased to the 5373 mIU/lt. The MRI showed a 25 × 22 mm cervical mass with parametrial invasion with rectal serosal involvement (figure 1). Biopsy confirmed the cervical choriocarcinoma. The patient underwent chemotherapy (EMA-CO).

Results The second case was a 31 year-old woman (gravida 2 para 2) was operated due to the ruptured ectopic with B-hcg of 29.251. On exploration, a ruptured and actively bleeding ectopic mass with size of 4 × 3 cm was noted on the ampulla of left fallopian tube as well as abundant haemoperitoneum with 600 cc of blood. A complete left salpingectomy was performed (fig-2,3). The final diagnosis was primary tubal choriocarcinoma of 2 cm in size which involved the whole layer of tubal wall and ruptured into pelvic cavity at the ampulla region. Computed tomography scans were negative for metastasis. Patient underwent monochemotherapy.

Conclusion Knowledge of the characteristics of the choriocarcinoma is very important for accurate diagnosis and treatment, especially when the tumor is localized on the rare locations and where a high level of serum B-hcg is absent. We aimed to implicate that when diagnosing the ectopic pregnancy, even very rare, the gestational choriocarcinoma should be kept in mind.

Disclosure Nothing to disclose

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