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EP1129 The association among cervical, anal and oral HPV infections in women with and without high-grade cervical lesions
  1. B Sehnal1,
  2. M Nipcova1,
  3. M Zikan1 and
  4. J Slama2
  1. 1Department of Gynaecology and Obstetrics, Hospital Na Bulovce and 1st School of Medicine, Charles University
  2. 2Department of Gynaecology and Obstetrics, General University Hospital and 1st School of Medicine, Prague, Czech Republic


Introduction/Background The human papillomavirus (HPV) can cause premalignant and malignant tumors in the anogenital and oropharyngeal regions.

Methodology A total of 718 immunocompetent women were enrolled in the study. The high-risk (HR) group consisted of 473 patients with biopsy-confirmed high-grade cervical lesion while the low-risk (LR) group consisted of other 245 women. All participants completed an anonymous self-administered questionnaire and were subjected to cervical, anal, and oral HPV genotyping using the Linear array HPV test.

Results A total of 81.4% women were infected in the cervix, 43.3% in the anus, and 2.7% in the oral cavity in the HR group in comparison with only 26.9%, 24.5%, and 1.4% in the low-risk LR group, respectively. The cervical and anal HPV infections were much more frequent in the HR patients (p<0.001); the difference in the oral HPV prevalence was not significant (p=0.511) between groups. Concurrent cervical-anal infection was observed in 39.3% of HR women and in 8.3% of the LR patients (p<0.001) and it significantly increased with the grade of cervical lesion (ptrend<0.001). The higher prevalence of concurrent cervical-oral, anal-oral, and cervical-anal-oral infections in HR women was statistically not significant according to the generally small oral HPV prevalence.

Conclusion All HPV infections occurred more often in HR than in LR women but not all results were statistically significant. The genotype HPV 16 was found in approximately half of all infections at all sites.

Disclosure This study has been supported by Charles University in Prague (UNCE 204065) and by Ministry of Health of the Czech Republic, grant nr. 17-32030A.

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