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P12 Risk factors for failure of bilateral sentinel lymph node mapping in early-stage cervical cancer
  1. A Bresset1,
  2. V Balaya1,
  3. B Guani2,
  4. L Magaud3,
  5. H Bonsang-Kitzis1,
  6. M Deloménie1,
  7. H-T Nguyen-Xuan1,
  8. M Koual1,
  9. R Montero Macias1,
  10. C Ngo1,
  11. A-S Bats1,
  12. P Mathevet2 and
  13. F Lécuru1
  1. 1Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European Hospital, Paris, France
  2. 2Gynecologic Department, University Hospital of Vaud, Lausanne, Switzerland
  3. 3Pôle IMER, Hospices Civils de Lyon, Lyon, France


Introduction/Background The objective of this study was to determine clinical, tumor and surgical factors associated with sucessful bilateral sentinel lymph node mapping (SBM) in early-stage cervical cancer.

Methodology We performed an ancillary work on the data of two prospective trials on SLN biopsy (SENTICOL I & II). Patients having lymph node dissection for FIGO IA-IIA cervical cancer were included between 2005 and 2012 from 25 French oncologic centers. Sentinel lymph node (SLN) was detected by a combined labeling technique (blue and isotopic).

Results 405 patients were included for analysis: SLNs were identified on at least one side of the pelvis in 381 patients (94.1%) and bilaterally in 326 patients (80.5%). No SLNs were found in 24 patients (6%). The mean age was 43 years [22–85 years]. Most patients (88.1%) had IB1 clinical FIGO stage. The majority of patients (71%) had squamous cells carcinoma. Surgeries were mainly performed by mini-invasive approach (368 patients - 90.9%). By multivariate analysis, SBM was associated with inclusion during the period 2009–2012 (ORa=2.24, 95%CI = [1.09–4.61], p=0.03) compared to the period 2005–2007. Failure of bilateral SLN mapping was associated with Age ≥ 70 years (ORa=0.02, 95%CI = [0.002–0.29], p=0.003), BMI >30 kg/m2 (ORa= 0.33, 95%CI = [0.15–0.75], p=0.01) and tumor size ≥ 20 mm (ORa=0.41, 95%CI = [0.19–0.87], p=0.02)

Conclusion A better experience of SLN biopsy technique improved SBM rate in early-stage cervical cancer. Age higher than 70 years, obesity and tumor larger than 20 mm decreased siignificantly SBM.

Disclosure Nothing to disclose.

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