Introduction/Background Serbia has incidence of cervical carcinoma 20,3/100000, what means twice than west Europe countries.Aim of this study was to evaluate the incidence of HPV infection and to identify specific types of human papiloma virus in cervical intraepithelial lesions CIN 2+ before conisatio and in healthy women without CIN2+.
Methodology The study was performed on a cohort of 53 patients with CIN 2+ and 84 patients without CIN+2, patients who during primary examination had already normal PAP smear test. Human Pappiloma Virus (HPV) genotyping was analyzed by multiple Polymerase Chain Reaction (PCR) methods.
Results The mean age of enrolled women was 37 (minimum of 20 and maximum 67 years. Among the patients with CIN2+, the presence of HPV by using PCR was detected in 24,58% (13patients) and among control group was 22,37%. The incidence of HPV was highest (66,1%) in women aged 30–40 years old and it decreased with age and was lowest (6,5%) among patients older than 50 years. The prevalence of oncogenic types of the virus was highest then presence low risk type in both group. Results of HPV typing showed that HPV 16,58 and 31 were the most common types detected among the patients with CIN2+and some of them have mulptiple infection.HR HPV type 16 was the most common type in control group and 31.LR HPV type 6 is most common type in both group. Surprisingly, in our population with CIN 2+ and control group we did not find any patients with type 18 and 11.
Conclusion Our study showed very low incidence of HPV infection in CIN2+ group,almost the same as in control healthy patients.We did not find any patients with type HRHPV18 and LRHPV11.Other factors could be reasons for developing CIN2+in our country because we were bombarding with depleted uranium and maybe it can has influence.
Disclosure Nothing to disclose
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