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EP1079 Clearance of HPV in women received conization related with mycoplasma and Ureaplasma
  1. CJ Kim1,
  2. SJ Lee1,
  3. KH Lee2,
  4. YS Lee2,
  5. JS Park3 and
  6. TC Park4
  1. 1Department of Obstetrics and Gynecology, Uijongbu St. Mary's Hospital The Catholic University of Korea College of Medicine, Uijongbu-si
  2. 2Department of Obstetrics and Gynecology
  3. 3Catholic University of Korea, Medical College, Seoul
  4. 4Uijongbu St. Mary's Hospital The Catholic University of Korea College of Medicine, Uijongbu-si, Republic of Korea


Introduction/Background Little is known about risk factors for persistent high-risk infection after cervical conization. We compared the duration of high risk HPV among women with cervical conization by exposure to sexually transmitted infections(STIs) using a real time PCR methods.

Methodology This study was conducted on 28 patients who received conization due to persistent CIN-1, CIN-2,3 and CIS at the St Paul's Hospital of the Catholic University of Korea from Jul, 2014 until Feb, 2018. They all were positive for high risk HPV at initial visit. A specimens were tested using realtime based assay, Anyplex II STI-7 (Seegene, Korea). tients were followed in 4–6 month interval with Pap smear and Anyplex TM Real time PCR HPV 28 detection method which detect 19 high-risk HPV genotype, 9 low-risk genotypes

Results The mean age was 39.3 years (Min-Max : 26–50) and mean follow-up month was 20.2 month(Min-Max :3–41 month). ASCUS, LSIL,ASCH and HSIL were 8,6,3 and 11 women. Single and multiple HPV detection was 14 and 14 (50%).

Of the women received conization, median clearance time of those multiple type HPV was 26 month and that was slightly longer than single type HPV(24.5 month, P>0.05). Mycoplasma, Chlamydia and Ureaplasma positive cases were 10(35.7%),1(3.6%) and 18(64.3%).The median clearance of women infected with Mycoplasma and Ureaplasma were 22.4 and 29.8 months. Ureaplasma positive women had longer clearance time compared with negative women(29.8 month vs 24.8 month p>0.05).

HPV types were related with clearance time. Mean clearance of alpha-9 group HPV(HPV-16,31,33,35,52,58) was shorter than alpha-7(HPV-18,39,45,59,68,70) and alpha-6(HPV-53,56,66). (20.9 month vs 28.8 month p<0.05).

Conclusion In a follow-up after conization, women with Ureaplasma showed relatively long time persistence. Management of this STI could reduces risk for high risk HPV persistence.

Disclosure Nothing to disclose

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