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EP1059 Effects of oral probiotics administration in the human papillomavirus infection and its intraepithelial cervical lesions
  1. MC Alonzo Martinez1,
  2. E Canovas Morales1,
  3. V Navarro-Lopez2,3 and
  4. E Cazorla Amoros1
  1. 1Gynecology and Obstetrics, Hospital Universitario de Torrevieja, Torrevieja
  2. 2Hospital Universitario del Vinalopó, Elche
  3. 3Grupo MiBioPath, Universidad Católica de Murcia, Guadalupe, Spain


Introduction/Background The human papillomavirus (HPV) infects 75% of sexually active women. Most of these infections are transitory and resolve spontaneously in less than two years. The persistence of high grade HPV genotypes is the main risk factor for cervical cancer and its precursory lesions. Recently, new evidence suggests that the state of vaginal microbiota plays an important role in the persistence and elimination of HPV. The main objective of our study is to observe the changes on the HPV infection and its intraepithelial cervical lesions after a long term administration of an specific oral probiotic formulation.

Methodology The study is a randomize double-blinded clinical intervention trial. The sample will be taken from patients that attend the Gynecological consult of Hospital Universitario de Torrevieja, Spain, from 2018–2020. They must comply with the inclusion and exclusion criteria. The study has been divided in two parts. In Part I, we will analyze the vaginal samples taken after the oral administration of the probiotic to a large sample of patients for 28 days. In this part, we will evaluate the presence of the probiotic strain in vaginal microbiota. In Part II, the treatment with probiotic vs placebo, will be administered to HPV-positive women and observe its effect on the infection status and its cervical lesions.

Results Preliminary results in Part I (ended on April 30th,2019) demonstrated, using massive sequencing techniques, that the administration of the oral probiotic allows for its vaginal colonization (Results details will be shown on the poster).

Conclusion Through this study we attempt to demonstrate that an oral probiotic can colonize the vagina and consequently change its microbiota. In Part II of the study, we will study if an oral probiotic facilitates the elimination of HPV. In consequence, we would achieved to decrease the persistence of the intraepithelial cervical lesions, and therefore, cervical cancer.

Disclosure Nothing to disclose

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