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EP1010 The clinical outcomes of neoadjuvant therapy with cisplatin plus mitomycin in BRCA1-mutated ovarian cancer
  1. K Kotiv1,
  2. A Sokolenko1,
  3. E Ulrikh1,2,
  4. A Sidoruk1,2,
  5. A Ivantsov1,
  6. T Gorodnova1,
  7. A Urmancheeva1,2,
  8. I Berlev1,2 and
  9. E Imyanitov1,2
  1. 1National Medical Research Center of Oncology named after N.N.Petrov
  2. 2North-Western State Medical University named after I.I.Mechnikov, Saint-Petersburg, Russian Federation

Abstract

Introduction/Background The aim of the study was to compare the effectiveness of neoadjuvant chemotherapy regimens (NACT): Mitomycin and Cisplatin (MP) vs Paclitaxel and Cisplatin/Carboplatin (TCb/TP) in advanced BRCA1-mutated ovarian cancer (BMOC).

Methodology In a prospective cohort of 13 patients (38–66 years (mean age 52 years) we analyzed the efficacy of Mitomycin (10 mg/m2) and Cisplatin (100 mg/m2) NACT administered intravenously every 3–4 weeks. The control group included 22 patients of retrospective cohort (38–67 years (mean age 51,9 years), who received standard 1-st line NACT (TCb/TP). Clinical efficacy was evaluated according to RECIST 1.1, histopathologic response - according to the Bohm scale (2015).

Results The objective response was observed in 13/13 (100%) patientsin MP group vs 9/22 (41%) patientsin TCb/TP group (p=0,0006). Complete surgical cytoreduction was achieved in all patients (13/13; 100%) after MP vs 13/22 (59%) cases in TCb/TP group (p=0,01). Complete pathological response was confirmed only in MP group - in 3 out of 13 patients (23%) vs 0/22 patients (0%) in TCb/TP group (p=0,04).

Conclusion The short-term results of the present study showed that the neoadjuvant chemotherapy with Cisplatin and Mitomycin is an effective option for BRCA1-associated advanced ovarian cancer treatment.

Disclosure Nothing to disclose.

https://doi.org/10.1136/ijgc-2019-ESGO.1054

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