Introduction/Background Ovarian cancer is usually diagnosed in advanced stage. The goal of debulking surgery should be no residual disease. This may lead to severe postoperative complications, prolonging hospital stay and delaying chemotherapy initiation. The aim of this study is to identify possible predictive factors and minimize the occurrence of postoperative complications.

Methodology We retrospectively reviewed the medical records of all patients that underwent primary (PDS) or interval (IDS) debulking surgery for advanced epithelial ovarian cancer (January 2018–December 2018) in two medical clinics. The clinicopathological characteristics, oncological and surgical results were described.

Results Out of total 79 patients with ovarian cancer, 49 met the eligibility criteria. The mean age was 61±12 years old and the majority of them, 44 (90%), had FIGO stage III serous adenocarcinoma. The median hospitalization was 8±3 days and the postoperative complications ranged from 0 to 100, with one death within 30days. A univariate analysis was conducted: There was a statistically significant difference (p-value=0.002) between primary and interval debulking surgery: PDS showed increased postoperative complications. Furthermore, Aletti score, prolonged surgery duration (>300 min), elevated preoperative CA-125 and postoperative intensive care unit (ICU) admission were statistically significant associated with increased postoperative complications (p-value <0.05). Last but not least, 17 patients underwent preoperative ‘Fagotti’ diagnostic laparoscopy. The ‘Fagotti group’ had less postoperative complications, but with no statistically significant difference.

Conclusion Aletti score, prolonged surgery duration, elevated CA-125, postoperative ICU admission and primary debulking surgery were statistically significant associated with more postoperative complications.‘Fagotti’ diagnostic laparoscopy could be a possible way to decrease postoperative complication but further investigation with more patients is needed.

Disclosure Nothing to disclose.