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EP1227 Nutritional interventions to improve clinical outcomes in ovarian cancer: a systematic review of randomized controlled trials
  1. C Marchetti1,
  2. MC Mele2,
  3. E Rinninella2,
  4. M Cintoni2,
  5. P Raoul2,
  6. G Scaletta3,
  7. A Gasbarrini2,
  8. G Scambia3 and
  9. A Fagotti3
  1. 1Fondazione Policlinico Agostino Gemelli, IRCCS, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, UOC di Ginecologia Oncologica, Roma
  2. 2Fondazione Policlinico A. Gemelli, IRCCS
  3. 3Fondazione Policlinico Agostino Gemelli, IRCCS, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, UOC di Ginecologia Oncologica, Rome, Italy


Introduction/Background Among all gynaecological neoplasms, ovarian cancer has the highest rate of disease-related malnutrition, representing an important risk factor of postoperative mortality and morbidity. Hence, the importance of finding effective nutritional interventions is crucial to improveovarian cancer patient‘s well-being and survival.

Methodology This systematic review of randomized controlled trials (RCTs) aims at assessing the effects of nutritional interventions on clinical outcomes such as overall survival, progression-free survival, length of hospital stay (LOS), complications following surgery and/or chemotherapy in ovarian cancer patients.

Methods Three electronic bibliographic databases — MEDLINE, Web of Science and Cochrane Central Register of Controlled Trials - were used to conduct a systematic literature search based on fixed inclusion and exclusion criteria, until December 2018.

Results A total of 14 studies were identified. Several early postoperative feeding interventions studies (n=8) were retrieved mainly demonstrating a reduction in LOS and an ameliorated intestinal recovery after surgery. Moreover, innovative nutritional approaches such as chewing gum intervention (n=1), coffee consumption (n=1), ketogenic diet intervention (n=2) or fruit and vegetable juice concentrate supplementation diet (n=1) and short-term fasting (n=1) have been shown as valid and well-tolerated nutritional strategies improving postoperative care.

Conclusion despite an acceptable number of prospective trials, there is still a lack of homogeneous and robust endpoints. In particular, there is an urgent need ofRCTs evaluating overall survival and progression-free survival during ovarian oncology treatments. Further high-quality studies are warranted, especially prospective study and large RCTs, with more homogeneous types of intervention and clinical outcomes, including a more specific sampling of ovarian cancer women, to identify appropriate and effective nutritional strategies for this cancer at high risk of malnutrition.

Disclosure Nothing to disclose.

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