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  • EP916 Lymph node involvement pattern and survival differences in a retrospective analysis of individual results prior to change our strategy about de role of lymphadenectomy in management of ovarian cancer

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EP916 Lymph node involvement pattern and survival differences in a retrospective analysis of individual results prior to change our strategy about de role of lymphadenectomy in management of ovarian cancer
  1. E Martínez Lamela1,
  2. J Molero Vílchez2,
  3. A Santiago Gómez3 and
  4. G Sánchez Rodillo4
  1. 1Oncologic Gynecology, Hospital Ntra Sra del Rosario, Obstetrics and Gynecology, University Hospital Infanta Leonor
  2. 2Oncologic Gynecology, Hospital Ntra. Sra. del Rosario, Madrid, Oncologic Gynecology, Clinica TocoGyn, Alcalá de Henares
  3. 3Medical Oncology
  4. 4Radiation Oncology, Institute of Advanced Techniques Against Cancer, Madrid, Spain

Abstract

Introduction/Background Our purpose was to analyse the Overall Survival (OS) and Disease-Free Survival (DFS) comparing subgrous with different tumor spread pattern.

Methodology A total of 118 patients with primary ovarian cancer who received complete cytoreductive surgery were included in current retrospective analysis. Mean age was 57 years (18–90). The histologic type most common was high grade serous carcinoma (48.6%). According to FIGO staging, patients were divided into initial (I–II, 66 cases) and advanced stages (III–IV, 74 cases). The main goal was to compare survival differences in all patients and among groups using standard statistical procedures.

Results In 92 cases lymphadenectomy were performed (lymph node involvement was detected in 14.3%, 20 cases), 78 cases pelvic and para-aortic, 5 cases only para-aortic and 9 cases only pelvic lymphadenctomy. Mean number of removed pelvic lymph nodes was 18 (9–38) (12 cases involved nodes, 8.6%) and 20 (10–51) para-aortic nodes (17 cases involved nodes, 12%). The median follow-up was 41.2 months (SD 33.8).

The estimated 5-year DFS and OS comparated rates respectively were: In all patients if lymphadenctomy was performed were 75 and 79.6%, vs no 72 and 57.6% (p=0.97 and p=0.01 Hazard ratio 2.31 (CI 95%, 1.14–4.68). If lymph node involvement was detected were 33.7 and 65.3%, vs no 76 and 79.3% (p=0.00 Hazard ratio 3.32 (CI 95%, 1.3–8.43) and p=0.17). In initial stages with lymphadenectomy were 88.5 and 88.5%, vs no 82.5 and 90% (p=0.32 and p=0.88). In advanced stages when lymphadenectomy was performed were 27.1 and 56.7%, vs no 65.4 and 46% (p=0.07 and p=0.30). In advanced stages with involvement lymph node were 31.5 and 62.4%, vs no 27.3 and 49.1% (p=0.81 and p=0,69).

Conclusion In light of our data, OS increased in case of patients who underwent with systematic pelvic and para-aortic lymphadenectomy.

Disclosure Nothing to disclose.

Abstract EP916 Figure 1
Abstract EP916 Figure 1

Results of univariante Cox of Disease-Free Survival (DFS) and Overall survival (OS): (A) Pelvic and

Abstract EP916 Figure 2
Abstract EP916 Figure 2

Overall survival (OS) in patients underwent pelvic and para-aortic lymphadenectomy. (A) Initial stag

https://doi.org/10.1136/ijgc-2019-ESGO.962

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