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EP911 Adjuvant chemotherapy versus surveillance in stage I non epithelial ovarian cancers: a single center experience
  1. L Hmida1,
  2. G Sahraoui2,
  3. I Marghli3,
  4. L Charfi2,
  5. R Doghri2,
  6. A Mokrani1,
  7. H Salhi3,
  8. M Driss2 and
  9. K Mrad2
  1. 1Medical Oncology
  2. 2Pathology
  3. 3Surgical Oncology, Salah Azaiez Institute, Tunis, Tunisia


Introduction/Background Non-epithelial ovarian tumors are uncomm malignancies which can be extremely challenging to treat. The aim of the study was to evaluate the effectiveness of chemotherapy in women with early stage disease.

Methodology Medical records of 84 patients diagnosed with stage I non epithelial ovarian cancer between 1985–2015 were reviewed. Tumor characteristics and treatment receipt were described.

Results Median age was 28 years [9–95]. Sixty-five had stage Ia disease at diagnosis while 19 presented with stage Ic disease. Fourteen had dysgerminoma (16.7%), 30 had immature teratoma (35.7%), 5 had yolk sac tumor (6%), 3 had embryonal carcinoma (3.6%), 3 had mixed germ cell tumor (3.6%), 28 had adult granulose cell tumor (33.3%) and one had juvenile granulose cell tumor (2.4%). Most of them (n=55, 65%) underwent fertility sparing surgery. Thirty-one (37%) received adjuvant platinum based chemotherapy, among them 17/65 were stage Ia disease and 14/19 were stage Ic disease. Fifty-two (62%) had surgery followed by active surveillance. Fertility sparing surgery was followed by adjuvant chemotherapy in 25% (n=21). After a median follow up of 45 months, 14 relapsed. Among them 6 received adjuvant chemotherapy and 8 underwent surgery followed by surveillance. The 5-year-disease-free-survival (DFS) and 5 year overall survival (OS) were respectively 79% and 46% in the chemotherapy arm and 80% and 51% in the surveillance arm with no statistically significant difference observed in DFS (p=0.4) and OS (p=0.3).

Conclusion Fertility sparing surgery with active surveillance is an option which should be discussed within a multi disciplinary team especially in young patients with early stage disease desirous of pregnancy.

Disclosure Nothing to disclose.

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