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EP892 How can collaboration with surgical oncologist change paradigm in the treatment of advanced ovarian cancer: a retrospective cohort study
  1. V Kopetskyi1,
  2. O Turckak2,
  3. N Tsip2,
  4. O Samokhvalova2 and
  5. O Kolesnik3
  1. 1Hepatopancreatobiliary | Gynecologic Oncology
  2. 2Gynecologic Oncology
  3. 3National Cancer Institute, Kyiv, Ukraine


Introduction/Background The pillar of treatment of advanced ovarian cancer is primary complete or at least optimal cytoreduction with further chemotherapy. Because of complexity of surgical debulking in upper abdomen there is a tendency to perform non-optimal debulking surgery or neoadjuvant chemotherapy that can compromise long-term results. We hypothesized that collaboration with surgical oncologist team treating patients with upper GI tumors can improve both number of primary cytoreductions and completeness of cytoreduction.

Methodology We have analyzed Prospective database of National cancer institute. In analysis were included patients older than 18 years old with stage III-IV of epithelian ovarian cancer treated in National cancer institute form January 2012 till November 2018. In September 2017 in National cancer institute peritoneal malignancies, treatment program was established. Our primary point was to compare amount of primary cytoreductive surgeries and completeness of cytoreduction during two periods: from January 2012 till august 2017 and from September 2017 till November 2018.

Results From 551 patient, after primary analysis we excluded 22 where only diagnostic procedures were performed. Among remaining 529 patients primary cytoreduction was performed in 256 cases (48.4%) and interval cytoreduction in 295 (51.6%). In primary cytoreduction group: from January 2012 to august 2017 complete or optimal cytoreduction was performed in 23.6% of cases, from September 2017 to November 2018 in 61.4% (p<0.05). In absolute numbers - 50 cases for the 5 year period vs 27 cases for the 15 month. In group where interval cytoreduction was performed: complete or optimal intervention were in 30% cases in period from 2012 to august 2017 and in 48,2% in period from September 2017 to November 2018. There were no postoperative mortality in both groups.

Conclusion Collaboration with surgical oncologist can improve both the quality of surgical debulking and amount of primary cytoreductions.

Disclosure Nothing to disclose.

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