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EP888 The impact of levels of biomarkers on overall survival in FIGO stage III–IV ovarian cancer
  1. A Karlsson1,
  2. E Lundin2,
  3. P Lukas1,
  4. G Lindahl3 and
  5. P Kjølhede2
  1. 1Department of Obstetrics and Gynecology, Linköping University Hospital
  2. 2Department of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Faculty of Medicine and Health Science, Linköping University
  3. 3Department of Oncology, Linköping University Hospital, Linköping, Sweden


Introduction/Background In this study we aim to analyse the impact of five biomarkers on overall survival (OS) in FIGO stage III-IV ovarian-, fallopian tube-, peritoneal- and abdominal cancer, together designated OC, in a cohort of women.

Methodology All 428 women with FIGO stage III-IV OC who were diagnosed with serous adenocarcinoma (high grade or grade not stated), endometrioid adenocarcinoma or clear-cell carcinoma in the South East Health Region in Sweden in the period January 2008 to November 2017 were included. Only the women who had undergone primary debulking surgery (PDS) or neoadjuvant chemotherapy (NACT) were included. Pre-treatment laboratory, demographic and clinical data were retrospectively retrieved from the patients‘ charts. The median value for each of the biomarkers (haemoglobin, thrombocytes, albumin, C-reactive protein (CRP) and CA-125) was calculated and the women were dichotomized as having above or below the median. OS was estimated using the Kaplan-Meier method. Comparison of groups was carried out using the Cox Proportional Hazards Regression Analysis. Adjustment was done for age, calendar year of treatment, body mass index and primary treatment modality (PDS/NACT followed by delayed PDS/NACT only).

Results The women had significantly shorter OS if the albumin level was under the median, or the thrombocytes, CRP or CA-125 levels were over the median. Women with the levels of all three biomarkers thrombocytes, albumin and CRP in adverse direction had significantly shorter OS than the women who had the level of at least one of these biomarkers in the favourable direction.

Conclusion The levels of thrombocytes, albumin, CRP and CA-125 as well as the combination of thrombocytes, albumin and CRP were independent predictors of OS in FIGO stage III–IV OC even when adjusted for treatment modality. This might imply that biologic factors are the most important determinant for OS in OC.

Disclosure Nothing to disclose.

Abstract EP888 Figure 1

Kaplan Meier cumulative proportion surviving in relation to level of A) hemoglobin concentration, B) thrombocytes, C) serum albumin, D) C-reactive protein, E) serum CA-125 and F) a compound variable of adverse directions of thrombocytes, serum albumin and C-reactive protein, measured prior to start of treatment. Hazard ratio estimated by using Cox Proportional Hazards Regression Analysis Crude and adjusted hazard ratios and 95% confidence intervals are presented. Adjusments were done simultaneously for age, calendar year of diagnosis, body mass index, treatment modality (primary debulking surgery, neoadjuvant chemotherapy followed by delayed primary debulking surgery, or neoadjuvant chemotherapy only) and FIGO stage

Abstract EP888 Table 1

Median concentration of biomarkers in blood

Abstract EP888 Table 2

Median survival and 5-year-survival in relation to levels of the biomarkers or in relation to the three biomarkers-variable

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