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EP842 Role of thyroid system in malignant transformation of ovaries in women with previously removed uterus
  1. E Frantsiyants,
  2. V Bandovkina,
  3. T Moiseenko,
  4. I Kaplieva,
  5. I Neskubina,
  6. A Menshenina,
  7. M Adamyan,
  8. N Chernikova,
  9. E Verenikina,
  10. T Myagkova and
  11. L Trepitaki
  1. Rostov Research Institute of Oncology, Rostov-on-Don, Russian Federation


Introduction/Background Thyroid hormones have a regulatory effect on the synthesis and metabolism of sex hormones by the ovaries. Hysterectomy (HE) in women with functioning ovaries, with benign uterine diseases, leads to homeostasis disorders, disruption of adaptation processes at all levels, exacerbation of menopausal disorders, and contributes to abnormal hypothalamus-pituitary-ovaries-thyroid neuroendocrine relationships. The purpose of the study was to analyze the functional activity of the thyroid gland in women with ovarian cancer (OC) with preserved or removed uterus.

Methodology In 74 menopausal patients with OC after HE (group 1) and primary OC (group 2), mean age 58.3±1.2, blood levels of thyrotropic hormone (TTH), thyroxine (T4), triiodothyronine (T3) and their free forms - FT4, FT3 (Immunotech, Czech) were determined by RIA. The values in 24 healthy donors were considered normal. All patients gave their voluntary informed consent for the study.

Results Blood levels of T4 in group 1 were 1.3 times lower, and in group 2–1.6 times higher than the norm. FT4 exceeded the norm in all patients - 1.8 times in group 1 and 1.4 times in group 2, while FT3 was decreased on average by 1.7 times. TTH levels in group 1 were decreased by 1.4 times, in group 2 - similar to the norm.

Conclusion Regardless of the presence or absence of the uterus at the time of the development of a malignant process in the ovaries, the pituitary-thyroid axis imbalance was observed, expressed in violation of direct and inverse relationships between peripheral hormones of the thyroid gland and TSH produced by the pituitary gland. Patients with tumor development in the ovaries preserved after HE showed an initial decrease in the thyroxin formation, not controlled by the pituitary, and secondary hypothyroidism.

Disclosure Nothing to disclose.

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