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EP766 Clinico-pathological features of ovarian granulosa cell tumours
  1. GO Abdulrahman Jnr,
  2. N Das and
  3. K Lutchman Singh
  1. Swansea Gynaecological Oncology Centre, Swansea Bay University Health Board, Swansea, UK


Introduction/Background Ovarian granulosa cell tumour (GCT) is a rare ovarian malignancy, which is infrequently reported in the literature. However, it generally has good prognosis. We aim to report our experience with GCT in our centre.

Methodology All patients that were diagnosed with GCT between 2011 and 2018 at the Swansea Gynaecological Oncology Centre were identified through our cancer database. Patient characteristics, treatment, pathology results and outcomes were retrospectively analysed.

Results 15 patients were diagnosed with GCT during the study period. This constitutes 2.1% of total ovarian malignancies diagnosed. The mean age of the women was 59.9 years (32–81 years). 13 women (86.6%) were diagnosed at FIGO Stage 1, 1 (6.7%) woman was diagnosed at FIGO Stage 3 while 1 was a recurrence after 20 years of initial diagnosis and surgery. Abdominal pain was the commonest presenting complaint. The case of recurrence presented with abdominal pain. Endometrial pathology was detected in 33.3% of patients. 80% were adult-type granulosa cell tumour while 6.7% was juvenile-type granulosa cell tumour. The mean follow-up was 61.7 months with an overall survival of 93.3%. 80% had positive inhibin, 33% had positive calretinin and 46.7% showed evidence of haemorrhage on histology. Only the recurrent tumour stained positive for epithelial membrane antigen (EMA) and CD56 on immunohistochemistry (IHC). 93.3% of the patients had laparotomy with majority having total abdominal hysterectomy, bilateral salpingo-oophorectomy and omentectomy except one patient that had unilateral oophorectomy as she desired fertility. GCTs appear to have a propensity for the left ovary as this accounted for 73% of the diagnosis.

Conclusion Granulosa cell tumour is a rare ovarian malignancy with favourable prognosis. Abdominal pain presentation with evidence of ovarian cyst on radiological imaging could suggest GCT. Although recurrence is rare, long term follow-up is required. Positive EMA and CD56 on IHC could possibly predict risk of recurrence.

Disclosure Nothing to disclose.

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